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Histamine II and Anti-Histaminics

Chemistry, Metabolism and Physiological and Pharmacological Actions

  • Book
  • © 1978

Overview

Editors:
  1. Mauricio Rocha e Silva

    1. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 18 / 2)

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Table of contents (15 chapters)

  1. Front Matter

    Pages II-XIX
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  2. Recent Developments of the Histamine Problem

    1. Pharmacological Actions

      • B. Mauricio Altura, S. Halevy, L. R. Johnson
      Pages 1-56

    2. Histamine Release

      • A. Goth, B. Uvnäs, N. Chakravarty
      Pages 57-108

    3. Metabolism and Excretion of Histamine

      • R. W. Schayer, H. Wetterqvist, Mauricio A. Beaven, Z. Horakova
      Pages 109-173

  3. Chemistry and Structure-Activity Relationships of Synthetic Anti-Histaminics

    1. Chemistry of Anti-H1 Histamine Antagonists

      • A. F. Casy
      Pages 175-214

    2. Structure-Activity Relationships of H1-Receptor Antagonists

      • W. Th. Nauta, R. F. Rekker
      Pages 215-249

    3. Chemistry and Structure-Activity Relationships of H2-Receptor Antagonists

      • C. Robin Ganellin
      Pages 251-294

  4. Mechanism of Action of Antihistaminics

    1. Kinetics of Antagonist Action

      • Mauricio Rocha e Silva
      Pages 295-332

    2. Competitive and Noncompetitive Antagonism

      • Frans G. Van Den Brink, Eric J. Lien
      Pages 333-367

    3. Naturally Occurring Antihistaminics in Body Tissues

      • G. Pelletier
      Pages 369-380

  5. Pharmacological Actions of Antihistaminics

    1. Bioassay of Antihistaminic Action

      • Mauricio Rocha e Silva, Abilio Antonio
      Pages 381-437

    2. Antianaphylactic and Antiallergic Effects

      • F. Hahn
      Pages 439-504

    3. Antiinflammatory Effects

      • C. G. Van Arman
      Pages 505-512

  6. Absorption, Distribution, Metabolism, and Elimination of Antihistamines

    1. Absorption, Distribution, Metabolism, and Elimination of Antihistamines

      • D. T. Witiak, N. J. Lewis
      Pages 513-560

  7. Therapeutic Action of Anti-Histaminics

    1. Antihistaminics as Central Nervous System Depressants

      • C. L. Faingold
      Pages 561-573

    2. Circulatory Shock, Histamine, and Antihistamines: Therapeutic Aspects

      • B. Mauricio Altura, S. Halevy
      Pages 575-602

  8. Back Matter

    Pages 603-702
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Keywords

About this book

In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on ,its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators.

Editors and Affiliations

  • Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Mauricio Rocha e Silva

Bibliographic Information

  • Book Title: Histamine II and Anti-Histaminics

  • Book Subtitle: Chemistry, Metabolism and Physiological and Pharmacological Actions

  • Editors: Mauricio Rocha e Silva

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-66445-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1978

  • Softcover ISBN: 978-3-642-66447-2Published: 18 November 2011

  • eBook ISBN: 978-3-642-66445-8Published: 27 November 2013

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XX, 702

  • Topics: Medicine/Public Health, general, Pharmacy

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