Histamine II and Anti-Histaminics

1. Front Matter

   Pages II-XIX

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2. Recent Developments of the Histamine Problem

   1. Pharmacological Actions

      • B. Mauricio Altura, S. Halevy, L. R. Johnson

      Pages 1-56

   2. Histamine Release

      • A. Goth, B. Uvnäs, N. Chakravarty

      Pages 57-108

   3. Metabolism and Excretion of Histamine

      • R. W. Schayer, H. Wetterqvist, Mauricio A. Beaven, Z. Horakova

      Pages 109-173

3. Chemistry and Structure-Activity Relationships of Synthetic Anti-Histaminics

   1. Chemistry of Anti-H1 Histamine Antagonists

      • A. F. Casy

      Pages 175-214

   2. Structure-Activity Relationships of H1-Receptor Antagonists

      • W. Th. Nauta, R. F. Rekker

      Pages 215-249

   3. Chemistry and Structure-Activity Relationships of H2-Receptor Antagonists

      • C. Robin Ganellin

      Pages 251-294

4. Mechanism of Action of Antihistaminics

   1. Kinetics of Antagonist Action

      • Mauricio Rocha e Silva

      Pages 295-332

   2. Competitive and Noncompetitive Antagonism

      • Frans G. Van Den Brink, Eric J. Lien

      Pages 333-367

   3. Naturally Occurring Antihistaminics in Body Tissues

      • G. Pelletier

      Pages 369-380

5. Pharmacological Actions of Antihistaminics

   1. Bioassay of Antihistaminic Action

      • Mauricio Rocha e Silva, Abilio Antonio

      Pages 381-437

   2. Antianaphylactic and Antiallergic Effects

      • F. Hahn

      Pages 439-504

   3. Antiinflammatory Effects

      • C. G. Van Arman

      Pages 505-512

6. Absorption, Distribution, Metabolism, and Elimination of Antihistamines

   1. Absorption, Distribution, Metabolism, and Elimination of Antihistamines

      • D. T. Witiak, N. J. Lewis

      Pages 513-560

7. Therapeutic Action of Anti-Histaminics

   1. Antihistaminics as Central Nervous System Depressants

      • C. L. Faingold

      Pages 561-573

   2. Circulatory Shock, Histamine, and Antihistamines: Therapeutic Aspects

      • B. Mauricio Altura, S. Halevy

      Pages 575-602

8. Back Matter

   Pages 603-702

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In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on ,its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators.

• Antihistaminikum
• Histamin
• chemistry
• metabolism
• research

• Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

  Mauricio Rocha e Silva

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