Teratology

1. Front Matter

   Pages I-X

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2. New Attitudes to Experimental Teratology

   1. Front Matter

      Pages 1-1

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   2. A Developmental Approach to Teratology

      • M. C. Johnston, R. M. Pratt

      Pages 2-16

   3. Chromosomal Animal Model of Human Disease. Fetal Trisomy and Developmental Failure

      • A. Gropp, B. Putz

      Pages 17-33

   4. Animal Models of Major Gene Defects

      • K. S. Brown

      Pages 34-48

   5. Cytotoxic Agents in Teratogenic Research

      • T. A. Connors

      Pages 49-79

3. Problems of Predictive Teratology

   1. Front Matter

      Pages 81-81

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   2. Polygenic Models in Teratological Testing

      • C. L. Berry, J. P. Germain

      Pages 83-102

   3. Behavioural Teratology

      • S. M. Barlow, F. M. Sullivan

      Pages 103-120

   4. Teratological Investigations in Laboratory Primates: Why, When and How to Use Them

      • D. E. Poswillo, I. R. Phillips

      Pages 121-135

   5. Screening Medicines for Teratogenicity: Problems of Interpretation

      • R. M. Atkinson

      Pages 136-146

4. Back Matter

   Pages 82-82

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5. Influencing the Fetal Milieu

   1. Front Matter

      Pages 147-147

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   2. Placental Causes of Maldevelopment

      • K. Benirschke

      Pages 148-164

   3. Future Prospects for Fetal Surgery

      • D. Sopher

      Pages 165-179

6. New Aspects of Developmental Teratology

   1. Front Matter

      Pages 181-181

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   2. Morphological and Behavioural Abnormalities Caused by Insults to the CNS in the Perinatal Period

      • J. Langman, W. Webster, P. Rodier

      Pages 182-200

   3. Polymorphisms: Their Lessons for Human Teratology

      • D. F. Roberts, J. Burn

      Pages 201-222

   4. The Impact of Malformation on the Emotional Development of the Child and his Family

      • A. Bentovim

      Pages 223-233

7. Back Matter

   Pages 235-240

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In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop­ mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem­ icals to damage the embryo; strict methods of screening for teratogenicity have be­ come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci­ entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.

• Laboratory
• biology
• chromosome
• drugs
• embryo
• embryology
• fat
• genes
• genetics
• growth
• molecular biology
• obstetrics
• pharmacology
• research
• screening

• Guy’s Hospital Medical School, London, England

  C. L. Berry

• Guy’s Hospital, London, England

  C. L. Berry

• Royal College of Surgeons of England, London, England

  D. E. Poswillo

• Queen Victoria Hospital, East Grinstead, England

  D. E. Poswillo

Policies and ethics