Fundamental Aspects of Neoplasia

1. Front Matter

   Pages i-xxiv

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2. Biology of Tumor Viruses

   1. Front Matter

      Pages 1-1

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   2. On the Evidence for Type-C RNA Tumor Virus Information and Virus-Related Reverse Transcriptase in Animals and in Human Leukemia Cells

      • D. Gillespie, R. E. Gallagher, R. G. Smith, W. C. Saxinger, R. C. Gallo

      Pages 3-27

   3. Evolution of Primate Type-C Viral Genes

      • R. E. Benveniste, C. J. Sherr, M. M. Lieber, R. Callahan, G. J. Todaro

      Pages 29-53

   4. The Mammary Tumor Viruses

      • D. H. Moore

      Pages 55-59

   5. Biochemical Evidence for Viral Involvement in Human Breast Cancer

      • J. Schlom, D. Colcher, R. Michalides, G. Schochetman, J. Young, S. Spiegelman et al.

      Pages 61-78

3. Tumor Immunology

   1. Front Matter

      Pages 79-79

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   2. Immunologic Properties of Cell Surface Antigens Induced by RNA Tumor Viruses

      • H. Bauer, R. Kurth, H. Gelderblom

      Pages 81-88

   3. Studies on the Mechanisms of Tumor Immunity: Some Recent Data on Cellular Immunity to Common, Possibly Embryonic Antigens in Mouse Sarcomas

      • K. E. Hellström, I. Hellström

      Pages 89-99

   4. Escape from Immune Control by the Shedding of Membrane Antigens: Influence on Metastatic Behavior of Tumor Cells

      • P. Alexander

      Pages 101-108

   5. Expression of HL-A Antigens on Lymphoblastoid Cells

      • R. A. Reisfeld, M. A. Pellegrino, S. Ferrone, S. Oh

      Pages 109-121

   6. Inhibitory Action of Poly A: Poly U on Tumor Growth: Enhancement of Host Immune Response?

      • F. Lacour, G. Delage, E. Fenster, J. Harel

      Pages 123-138

   7. The Problem of Cancer Immunotherapy in Perspective

      • O. J. Plescia, A. Smith, K. Grinwich, C. Feit

      Pages 139-151

4. Clinical Aspects

   1. Front Matter

      Pages 153-153

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   2. Immunotherapy of Cancer: Concepts and Problems

      • C. F. McKhann

      Pages 155-161

   3. Chemotherapy, Supportive Care, and Immunotherapy of Cancer—from Research Tools to Therapeutic Modalities

      • I. Djerassi, J. Sun Kim, U. Suvansri

      Pages 163-180

   4. Immunologic and Clinical Responses to Active Immunotherapy of Malignant Melanoma

      • D. L. Morton, S. H. Golub, H. L. Sulit, R. K. Gupta, F. R. Eilber, E. C. Holmes et al.

      Pages 181-201

   5. Viral Etiology of Human Osteosarcoma: Evidence Based on Response to Tumor-Specific Transfer Factor and on Immunoepidemiologic Studies

      • H. H. Fudenberg, V. S. Byers, A. S. Levin

      Pages 203-212

   6. Evidence for RNA Virus Associated with Human Transitional Cell Cancers of the Urinary Tract

      • E. E. Fraley, A. Y. Elliott, A. E. Castro, P. H. Cleveland, D. L. Bronson, T. R. Hakala et al.

      Pages 213-228

   7. Trials with Poly A:Poly U as Adjuvant Therapy Complementing Surgery in Randomized Patients with Breast Cancer

      • J. Lacour

      Pages 229-232

The control of cancer is at once a major public health problem and a problem of fundamental biologic interest. As a result of technologic developments and new insights in the realm of molecular biology, new and important approaches to an understanding of neoplasia are now possible. Several aspects of neoplasia are clearly of microbiologic interest, including the role of viruses in the etiology of cancer, control of the immune response to tumor cells, and the susceptibility of tumor-bearing hosts to overwhelming infection as a result of immuno­ deficiency. Recent advances in these areas led us to organize this symposium, and, through this publication, to record some of the progress being made in laboratories around the world in understanding some of the basic aspects of the cancer problem. This symposium was held as part of the commemoration of the twentieth anniversary of the Waksman Institute of Microbiology. Dr. Waksman's devo­ tion to the study of the smallest forms of life and the commitment of the Waksman Institute to the free pursuit of knowledge are the underpinnings of the institute's research eHorts in the broad area of microbiology, including the problem of neoplasia. It is of interest to note that actinomycin, one of the earliest antibiotics discovered in Waksman's laboratory, was also one of the first compounds found to be clinically useful in the treatment of certain types of cancer.

• Immunologie
• Immunotherapie
• Krebs
• Viruskrankheit
• antibiotics
• cancer
• infection
• molecular biology
• therapy
• tumor

• Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA

  A. Arthur Gottlieb

• Institute of Microbiology, Rutgers University, New Brunswick, USA

  Otto J. Plescia

• The Medical Center, University of Alabama, Birmingham, USA

  David H. L. Bishop

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