Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

1. Front Matter

   Pages i-iii

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2. Theoretical Aspects of Structure and Assembly of Viral Envelopes

   • Herbert A. Blough, John M. Tiffany

   Pages 1-30

3. Latent Herpes Simplex Virus and the Nervous System

   • Jack G. Stevens

   Pages 31-50

4. Temperature-Sensitive Mutants of Herpesviruses

   • P. A. Schaffer

   Pages 51-100

5. Inhibition of the Multiplication of Enveloped Viruses by Glucose Derivatives

   • C. Scholtissek

   Pages 101-119

6. Back Matter

   Pages 121-129

   PDF

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double­ stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes­ viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.

• Antigen
• Immunität
• animals
• biology
• cell
• cell membrane
• genes
• immunology
• infection
• infections
• microbiology
• virus

• Basle, Switzerland

  W. Arber, N. K. Jerne

• Philadelphia, USA

  W. Henle, P. Koldovský, H. Koprowski

• Martinsried, Germany

  P. H. Hofschneider

• London, UK

  J. H. Humphrey

• Copenhagen, Denmark

  O. Maaløe

• Gießen, Germany

  R. Rott

• Wilhelmshaven, Germany

  H. G. Schweiger

• Rehovot, Israel

  M. Sela

• Prague, Czech Republic

  L. Syruček

• Seattle, USA

  P. K. Vogt

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