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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

Volume 70

  • Book
  • © 1975

Overview

Editors:
  1. W. Arber

    1. Basle, Switzerland

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  2. W. Henle

    1. Philadelphia, USA

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  3. P. H. Hofschneider

    1. Martinsried, Germany

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  4. J. H. Humphrey

    1. London, UK

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  5. N. K. Jerne

    1. Basle, Switzerland

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  6. P. Koldovský

    1. Philadelphia, USA

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  7. H. Koprowski

    1. Philadelphia, USA

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  8. O. Maaløe

    1. Copenhagen, Denmark

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  9. R. Rott

    1. Gießen, Germany

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  10. H. G. Schweiger

    1. Wilhelmshaven, Germany

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  11. M. Sela

    1. Rehovot, Israel

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  12. L. Syruček

    1. Prague, Czech Republic

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  13. P. K. Vogt

    1. Seattle, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 70)

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Table of contents (4 chapters)

  1. Front Matter

    Pages i-iii
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  2. Theoretical Aspects of Structure and Assembly of Viral Envelopes

    • Herbert A. Blough, John M. Tiffany
    Pages 1-30

  3. Latent Herpes Simplex Virus and the Nervous System

    • Jack G. Stevens
    Pages 31-50

  4. Temperature-Sensitive Mutants of Herpesviruses

    • P. A. Schaffer
    Pages 51-100

  5. Inhibition of the Multiplication of Enveloped Viruses by Glucose Derivatives

    • C. Scholtissek
    Pages 101-119

  6. Back Matter

    Pages 121-129
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Keywords

About this book

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double­ stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes­ viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.

Editors and Affiliations

  • Basle, Switzerland

    W. Arber, N. K. Jerne

  • Philadelphia, USA

    W. Henle, P. Koldovský, H. Koprowski

  • Martinsried, Germany

    P. H. Hofschneider

  • London, UK

    J. H. Humphrey

  • Copenhagen, Denmark

    O. Maaløe

  • Gießen, Germany

    R. Rott

  • Wilhelmshaven, Germany

    H. G. Schweiger

  • Rehovot, Israel

    M. Sela

  • Prague, Czech Republic

    L. Syruček

  • Seattle, USA

    P. K. Vogt

Bibliographic Information

  • Book Title: Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

  • Book Subtitle: Volume 70

  • Editors: W. Arber, W. Henle, P. H. Hofschneider, J. H. Humphrey, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syruček, … P. K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-66101-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1975

  • Softcover ISBN: 978-3-642-66103-7Published: 11 November 2011

  • eBook ISBN: 978-3-642-66101-3Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IV, 136

  • Topics: Medicine/Public Health, general, Biomedicine general, Life Sciences, general

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