Regulation of Transcription and Translation in Eukaryotes

1. Front Matter

   Pages I-VII

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2. Chromosome Structure and Function

   1. The Organization of Sequences in Chromosomal DNA

      • C. A. Thomas Jr.

      Pages 1-30

   2. Gene Masking in Cell Differentiation: The Role of Non-Histone Chromosomal Proteins

      • J. Paul, R. S. Gilmour, I. A. R. More, A. J. MacGillivray, D. Rickwood

      Pages 31-38

   3. Biosynthesis and Enzymatic Modifications of Histones

      • D. Gallwitz

      Pages 39-57

   4. Pretranslational Control in Embryonic Differentiation

      • H. Tiedemann

      Pages 59-80

3. Transcription I

   1. Formation and Regulation of Messenger RNA in Animal Cells

      • Klaus Scherrer

      Pages 81-104

   2. Transcription and Processing of Adenovirus RNA in Productive Infection

      • Lennart Philipson, Uno Lindberg, Torgny Persson, Björn Vennström

      Pages 105-123

4. Transcription II

   1. Double-Stranded Viral and Cellular DNA’s as Templates for Purified Mammalian DNA-Dependent RNA Polymerases

      • P. Chambon, J. L. Mandel, F. Gissinger, C. Kedinger, M. Gross-Bellard, P. Hossenlopp

      Pages 125-138

   2. Studies on in vitro RNA Synthesis by RNA Polymerases from Rat Liver Tissue

      • K. H. Seifart, A. Ferencz, B. Benecke

      Pages 139-162

   3. A Protein Factor Influencing Mammalian RNA Polymerase B

      • Hans Stein, Horst Hameister, Claude Kedinger

      Pages 163-177

   4. Transcription in Mitochondria

      • E. Wintersberger

      Pages 179-193

   5. Expression of the Mitochondrial Genome in Wild Type and in an Extranuclear Mutant of Neurospora Crassa

      • H. Küntzel, Z. Barath, I. Ali, J. Kind, H. H. Althaus, H. C. Blossey

      Pages 195-210

5. Translation I

   1. Structure and Function of Bacterial Ribosomes

      • H. G. Wittmann

      Pages 211-212

   2. Initiation of Protein Synthesis in Prokaryotes

      • M. Grunberg-Manago, Th. Godefroy-Colburn, A. D. Wolfe, P. Dessen, D. Pantaloni, M. Springer et al.

      Pages 213-249

   3. Translational Control in Eukaryotic Organisms

      • William A. Strycharz, Marjut Ranki, Kjeld A. Marcker

      Pages 251-256

   4. The Mechanism of Subunit Interaction as a Key to the Understanding of Ribosome Function

      • Hans Noll, Markus Noll, Bern Hapke, Gerbrand van Dieijen

      Pages 257-311

6. Translation II

   1. Isoacceptor tRNA’s

      • M. Staehelin

      Pages 313-321

   2. Functional and Modulated Adaptation of tRNA to Fibroin Biosynthesis in the Silk Gland of Bombyx mori L.

      • J. P. Garel, A. Fournier, J. Daillie

      Pages 323-333

   3. Functional Characterization of Five Initiation Factors for Mammalian Protein Synthesis

      • Max H. Schreier, Theophil Staehelin

      Pages 335-349

7. Back Matter

   Pages 351-352

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This volume represents the proceedings of the 24th Mos­ bach Colloquium on "Regulation of Transcription and Trans­ lation in Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany, under the auspices of the Gesellschaft fiir Biologische Chemie. To the three of us (H. KERSTEN, P. KARLSON and myself) who were commissioned with the invitation of speakers, it was a difficult decision as to whether we should attempt to cover with some twenty contributions as many aspects of this broad topic as possible, or to sacrifice the intellectually perhaps more pleasing but more specula­ tive concepts and to concentrate on a few aspects of gene expression in reasonable detail. We unanimously decided on the latter course, leaving such important and timely topics as for example, hormone action, cyclic AMP and reverse transcription to the proceedings of other symposia, and con­ centrating on the four questions which are most basic to an understanding of the mechanisms of transcription and trans­ lation and for which fragmentary but nonetheless reliable experimental results have become available within the last few years. These are the structure of chromatin, the syn­ thesis of messenger RNA, the structure of the active ribo­ some, and the role of initiation factors in protein synthesis.

• RNA
• Regulation
• eukaryotes
• gene expression
• transcription
• translation

• Institut für Molekulare Genetik, Zoologisches Institut der Universität, Heidelberg, Neuenheimer Feld, Federal Republic of Germany

  E. K. F. Bautz

• Physiologisch-Chemisches Institut der Universität, Marburg, Federal Republic of Germany

  P. Karlson

• Physiologisch-Chemisches Institut der Universität, Erlangen, Federal Republic of Germany

  H. Kersten

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