Skip to main content

Current Topics in Microbiology and Immunology

Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 57

  • Conference proceedings
  • © 1972

Overview

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 57)

This is a preview of subscription content, log in via an institution to check access.

Access this book

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (5 papers)

Keywords

About this book

Phenomena as diverse as tuberculin sensitivity, delayed sensitivity to soluble proteins other than tuberculin, contact allergy, homograft rejection, experimental autoallergies, and the response to many microorganisms, have been classified as members of the class of immune reactions known as delayed or cellular hypersensitivity. Similarities in time course, histology, and absence of detectable circulating immunoglobulins characterize these cell-mediated immune reactions in vivo. The state of delayed or cellular hypersensitivity can be transferred from one animal to another by means of sensitized living lymphoid cells (CHASE, 1945; LANDSTEINER and CHASE, 1942; MITCHISON, 1954). The responsible cell has been described by GOWANS (1965) as a small lymphocyte. Passive transfer has also been achieved in the human with extracts of sensitized cells (LAWRENCE, 1959). The in vivo characteristic of delayed hypersensitivity from which the class derives its name is the delayed skin reaction. When an antigen is injected intradermally into a previously immunized animal, the typical delayed reaction begins to appear after 4 hours, reaches a peak at 24 hours, and fades after 48 hours. It is grossly characterized by induration, erythyma, and occasionally necrosis. The histology of the delayed reaction has been studied by numerous investigators (COHEN et al. , 1967; GELL and HINDE, 1951; KOSUNEN, 1966; KOSUNEN et al. , 1963; MCCLUSKEY et al. , 1963; WAKSMAN, 1960; WAKSMAN, 1962). Initially dilatation of the capillaries with exudation of fluid and cells occurs.

Editors and Affiliations

  • Basle, Switzerland

    W. Arber, N. K. Jerne

  • Canada

    W. Braun

  • Freiburg, Germany

    R. Haas

  • Philadelphia, USA

    W. Henle, P. Koldovský, H. Koprowski

  • Munich, Germany

    P. H. Hofschneider

  • Copenhagen, Denmark

    O. Maaløe

  • Gießen, Germany

    R. Rott

  • Wilhelmshaven, Germany

    H. G. Schweiger

  • Rehovot, Israel

    M. Sela

  • Prague, Czech Republic

    L. Syruček

  • Seattle, USA

    P. K. Vogt

  • Würzburg, Germany

    E. Wecker

Bibliographic Information

  • Book Title: Current Topics in Microbiology and Immunology

  • Book Subtitle: Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 57

  • Editors: W. Arber, W. Braun, R. Haas, W. Henle, P. H. Hofschneider, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syruček, P. K. Vogt, E. Wecker

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-65297-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1972

  • Softcover ISBN: 978-3-642-65299-8Published: 11 November 2011

  • eBook ISBN: 978-3-642-65297-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IV, 224

  • Topics: Medicine/Public Health, general, Biomedicine general, Life Sciences, general

Publish with us