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Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action

Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970

  • Conference proceedings
  • © 1971

Overview

Editors:
  1. Fred E. Hahn

    1. Department of Molecular Biology, Walter Reed Army Institute of Research, USA

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Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 2)

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Table of contents (28 papers)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  3. Antibiotics and Nucleic Acids

    1. Kinetics of Binding of Drugs to DNA

      • D. M. Crothers
      Pages 10-20

    2. The Binding of Actinomycin D to DNA

      • Robert D. Wells
      Pages 21-32

    3. Interaction of Antitumor Antibiotics with DNA: Studies on Sibiromycin

      • Georgii F. Gause, Yu. V. Dudnik
      Pages 33-39

    4. Anthramycin

      • Susan B. Horwitz
      Pages 40-47

    5. Inhibition of RNA Synthesis by Quinone Antibiotics

      • Walter Kersten
      Pages 48-57

    6. Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis

      • Helga Kersten
      Pages 58-68

  4. Antimalarials and Nucleic Acids

    1. Chloroquine Binding to Nucleic Acids: Characteristics, Biological Consequences, and a Proposed Binding Model for the Interaction

      • K. Lemone Yielding, Lerena W. Blodgett, Helene Sternglanz, David Gaudin
      Pages 69-90

    2. A Preliminary Nuclear Magnetic Resonance Study of the Effect of pH on the Structure of Chloroquine Diphosphate

      • Thomas A. Victor, Fred E. Hahn, Elizabeth A. Hansen
      Pages 91-102

    3. Effects of Chloroquine and Some Related Compounds on Aminoacylation of Transfer Ribonucleic Acids

      • Karl H. Muench, Michael Deldin, Julio C. Pita Jr.
      Pages 103-112

    4. Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects on Various Enzymatic Reactions in Vitro

      • David J. Holbrook Jr., Leona P. Whichard, Carl R. Morris, Lidia A. White
      Pages 113-125

    5. Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding

      • George E. Bass, Donna R. Hudson, Jane E. Parker, William P. Purcell
      Pages 126-133

  5. Alkaloids, Natural Polyamines and DNA

    1. Interactions of Alkaloids with DNA

      • Fred E. Hahn, Anne K. Krey
      Pages 134-151

    2. Physical Studies on the Interaction of Lysergic Acid Diethylamide and Trypanocidal Dyes with DNA and DNA-Containing Genetic Material

      • Thomas E. Wagner
      Pages 152-162

    3. Comments on the Interaction of LSD with DNA

      • K. Lemone Yielding, Helene Sternglanz
      Pages 163-165

    4. The Interaction of Polyamines with Nucleic Acids

      • Edward J. Herbst, Robert B. Tanguay
      Pages 166-180

  6. Intercalation Into Supercoiled DNA

    1. The Use of Intercalative Dyes in the Study of Closed Circular DNA

      • William Bauer, Jerome Vinograd
      Pages 181-215

    2. Binding of Drugs to Supercoiled Circular DNA: Evidence for and against Intercalation

      • Michael Waring
      Pages 216-231

  7. Synthetic Drugs and Dyes Binding to Nucleic Acids

    1. Mode of Action of Miracil D

      • I. Bernard Weinstein, Erich Hirschberg
      Pages 232-246
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Keywords

Editors and Affiliations

  • Department of Molecular Biology, Walter Reed Army Institute of Research, USA

    Fred E. Hahn

Bibliographic Information

  • Book Title: Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action

  • Book Subtitle: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970

  • Editors: Fred E. Hahn

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-642-65141-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1971

  • Softcover ISBN: 978-3-642-65143-4Published: 06 January 2012

  • eBook ISBN: 978-3-642-65141-0Published: 06 December 2012

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: X, 400

  • Topics: Cell Biology, Pharmacology/Toxicology

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