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Mechanisms of B Cell Neoplasia 1998

Proceedings of the Workshop held at the Basel Institute for Immunology 4th–6th October 1998

  • Conference proceedings
  • © 1999

Overview

Editors:
  1. Fritz Melchers

    1. Basel Institute for Immunology, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael Potter

    1. Laboratory of Genetics Building 37, Room 2B04, National Cancer Institute National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 246)

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Table of contents (49 papers)

  1. Front Matter

    Pages I-XXIX
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  2. B Cell and Plasma Cell Development

    1. Front Matter

      Pages 1-1
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    2. The Formation and Selection of Cells Expressing PreB Cell Receptors and B Cell Receptors

      • E. ten Boekel, T. Yamagami, J. Andersson, A. G. Rolink, F. Melchers
      Pages 3-10

    3. Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development

      • R. Ceredig, A. G. Rolink, F. Melchers, J. Andersson
      Pages 11-19

    4. Negative Selection of Self-reactive B Lymphocytes Involves Complement

      • M. Carroll
      Pages 21-29

    5. Cross-talk Between CD44 and c-Met in B cells

      • T. E. I. Taher, R. van der Voort, L. Smit, R. M. J. Keehnen, E. J. M. Schilder-Tol, M. Spaargaren et al.
      Pages 31-38

    6. The Transition from Immature to Mature B Cells

      • A. G. Rolink, F. Melchers, J. Andersson
      Pages 39-44

    7. CD21highIgMhigh Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions

      • F. Martin, J. F. Kearney
      Pages 45-52

    8. Do Germinal Centers Have a Role in the Generation of Lymphomas?

      • K. Yang, M. Davila, G. Kelsoe
      Pages 53-62

    9. Role of Complement Receptors CD21/CD35 in B Lymphocyte Activation and Survival

      • M. Carroll
      Pages 63-69

    10. Long-lived Plasma Cells Survive Independent of Antigen

      • R. A. Manz, G. Cassese, A. Thiel, A. Radbruch
      Pages 71-75

  3. Chemokines and Chemokine Receptors

    1. Front Matter

      Pages 77-77
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    2. Regulation of Expression of Chemokine Receptor BLR1/CXCR5 during B Cell Maturation

      • V. Pevzner, I. Wolf, R. Burgstahler, R. Förster, M. Lipp
      Pages 79-85

    3. Chemokines and B-cell Homing to Follicles

      • J. G. Cyster, V. N. Ngo, E. H. Ekland, M. D. Gunn, J. D. Sedgwick, K. M. Ansel
      Pages 87-93

    4. A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes

      • C. Schaniel, F. Sallusto, P. Sideras, F. Melchers, A. G. Rolink
      Pages 95-101

    5. Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells

      • P. Ghia, C. Schaniel, A.G Rolink, L. M. Nadler, A. A. Cardoso
      Pages 103-110

    6. Susceptibility Genes for AIDS and AIDS-Related Lymphoma

      • C. S. Rabkin, S. Sei
      Pages 111-115

    7. Molecular Mechanisms of T Helper Cell Differentiation and Tissue-specific Migration

      • D. D’Ambrosio, P. Panina-Bordignon, L. Rogge, F. Sinigaglia
      Pages 117-122

    8. The Role of Chemokine Receptors in Directing Traffic of Naive, Type 1 and Type 2 T Cells

      • F. Sallusto, B. Palermo, A. Hoy, A. Lanzavecchia
      Pages 123-129

    9. A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

      • Markus H. Gräler, Günter Bernhardt, Martin Lipp
      Pages 131-137
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Keywords

About this book

Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog­ ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri­ ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol­ ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen­ eral topics and themes, the papers are organized into five sec­ tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.

Editors and Affiliations

  • Basel Institute for Immunology, Basel, Switzerland

    Fritz Melchers

  • Laboratory of Genetics Building 37, Room 2B04, National Cancer Institute National Institutes of Health, Bethesda, USA

    Michael Potter

Bibliographic Information

  • Book Title: Mechanisms of B Cell Neoplasia 1998

  • Book Subtitle: Proceedings of the Workshop held at the Basel Institute for Immunology 4th–6th October 1998

  • Editors: Fritz Melchers, Michael Potter

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-60162-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1999

  • Softcover ISBN: 978-3-642-64283-8Published: 24 November 2011

  • eBook ISBN: 978-3-642-60162-0Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XXIX, 415

  • Number of Illustrations: 7 illustrations in colour

  • Topics: Immunology, Cancer Research, Internal Medicine

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