Trends in Contrast Media

1. Front Matter

   Pages I-XI

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2. Iodinated Contrast Media

   1. Front Matter

      Pages 1-1

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   2. History of lodinated Contrast Media

      • H. M. Pollack

      Pages 3-19

   3. Design of X-ray Contrast Agents

      • G. L. Wolf

      Pages 21-30

   4. Biological Variation, Reproducibility, and Predictability of Experimental Research in Animals

      • O. Svendsen, A. Kornerup Hansen

      Pages 31-41

   5. Experimental Testing of Iodinated Contrast Media Before Human Testing

      • R. Towart, K. Golman

      Pages 43-56

   6. Phase I, II, III, and IV Studies: Good Clinical Practice

      • I. M. Stilbo

      Pages 57-61

   7. Currently Available Iodinated Contrast Media

      • F. Stacul

      Pages 63-74

   8. Clinical Doses of Contrast Media

      • R. A. Older

      Pages 75-80

   9. Determination of Glomerular Filtration Rate with Contrast Media

      • T. Almén, B. Frennby, G. Sterner

      Pages 81-94

   10. Neurotoxicity

       • M. Leonardi, R. Agati

       Pages 95-102

   11. Nephrotoxicity

       • H. S. Thomsen

       Pages 103-116

   12. Adverse Reactions to Iodinated Radiographic Contrast Media

       • R. H. Cohan, J. H. Ellis

       Pages 117-132

   13. Treatment of Adverse Reactions

       • W. H. Bush Jr.

       Pages 133-140

   14. Hepatic Agents

       • P. Leander

       Pages 141-147

   15. Lymphatic Agents

       • E. R. Wisner, R. W. Katzber

       Pages 149-158

3. Magnetic Resonance Contrast Media

   1. Front Matter

      Pages 159-159

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   2. Chemical Synthesis of Paramagnetic Complexes

      • J. F. Desreux, D. Gilsoul

      Pages 161-168

   3. Preparation and Structure-Activity Relationships of Particulate Magnetic Agents

      • A. Nævestad, S. L. Fossheim, A. K. Fahlvik

      Pages 171-181

   4. Magnetic Resonance Contrast Agents of Increased Specificity

      • H.-J. Weinmann

      Pages 183-194

The use 0\ contrast media within diagnostic radiology has been firmly established for many years now. Radiologic contrast media render immense services in daily clinical practice to innumerable patients all over the world. When the new cross­ sectional modalities such as computed tomography and magnetic resonance ima­ ging were introduced into clinical practice it rapidly became evident that the judi­ cious use of contrast media allows the optimal exploitation of the great diagnostic potential of these revolutionary methods. More recently, efforts to create specific contrast media for ultrasound imaging have been successful, and the first benefi­ cial results of their application in daily practice are now evident. The aim of this book is to bring together the results of the tremendous research that has been performed during recent years in order to develop specific contrast media for magnetic resonance imaging and ultrasonography and also to develop safer contrast media for the classical radiologic techniques as well as computed tomography. Moreover, the book provides a comprehensive overview of the indica­ tions for and applications of these new contrast media in clinical radiology. Finally, risks, side-effects, and complications which may occur with the use of these drugs are covered appropriately. The three editors are leading and well-known experts in their specific field. They have been very successful in ensuring the collaboration of so many intern~tionally known specialists to cover the different topics dealt with in this book.

• Kontrastmittel
• Magnetic Resonance
• Magnetresonanz
• Radiopharmazeutika
• Tumor
• Ultraschall
• contract media
• iodinated contrast media
• jodierte Kontrastmittel
• radiopharmaceuticals
• ultrasound

• Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev, Denmark

  Henrick S. Thomsen

• Département de Chimie Organique & Laboratoire RMN, Université de Mons-Hainaut, Mons, Belgium

  Robert N. Muller

• Department of Radiology, UCSD Medical Center, San Diego, USA

  Robert F. Mattrey

Policies and ethics