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Origin and Evolution of the Vertebrate Immune System

  • Book
  • © 2000

Overview

Editors:
  1. Louis Pasquier

    1. Basel Institute for Immunlogy, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Gary W. Litman

    1. All Children’s Hospital, University of South Florida, St. Petersburg, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 248)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-IX
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  2. Bridge to Invertebrates

    1. Front Matter

      Pages 1-1
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    2. New Approaches Towards an Understanding of Deuterostome Immunity

      • J. P. Rast, Z. Pancer, E. H. Davidson
      Pages 3-16

    3. The Antimicrobial Host Defense of Drosophila

      • M. Meister, C. Hetru, J. A. Hoffmann
      Pages 17-36

    4. Origin and Evolution of the Complement System

      • M. Nonaka
      Pages 37-50

  5. Origin of Receptors

    1. Front Matter

      Pages 157-157
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    2. The Phylogenetic Origin of Antigen-Specific Receptors

      • L. Du Pasquier
      Pages 159-185

  6. Evolution of Receptors

    1. Front Matter

      Pages 187-187
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    2. Immunoglobulin Isotypes: Structure, Function, and Genetics

      • E. BengtĂ©n, M. Wilson, N. Miller, L. W. Clem, L. Pilström, G. W. Warr
      Pages 189-219

    3. Evolution of Vertebrate Immunoglobulin Variable Gene Segments

      • T. Ota, T. Sitnikova, M. Nei
      Pages 221-245

  7. Elasmobranchs

    1. Front Matter

      Pages 247-247
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    2. The Immune System of Cartilaginous Fish

      • M. F. Flajnik, L. L. Rumfelt
      Pages 249-270

    3. Immune-Type Diversity in the Absence of Somatic Rearrangement

      • J. A. Yoder, G. W. Litman
      Pages 271-282

  8. Somatic Diversification

    1. Front Matter

      Pages 283-283
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Keywords

About this book

The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop­ ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte­ brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or­ igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo­ lecular contexts in which the mechanism was introduced.

Editors and Affiliations

  • Basel Institute for Immunlogy, Basel, Switzerland

    Louis Pasquier

  • All Children’s Hospital, University of South Florida, St. Petersburg, USA

    Gary W. Litman

Bibliographic Information

  • Book Title: Origin and Evolution of the Vertebrate Immune System

  • Editors: Louis Pasquier, Gary W. Litman

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-59674-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2000

  • Softcover ISBN: 978-3-642-64078-0Published: 04 October 2011

  • eBook ISBN: 978-3-642-59674-2Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 326

  • Topics: Immunology, Zoology, Human Genetics, Microbiology

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