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Retinoids

The Biochemical and Molecular Basis of Vitamin A and Retinoid Action

  • Book
  • © 1999

Overview

Editors:
  1. Heinz Nau

    1. Department of Food Toxicology Center of Food Science, School of Veterinary Medicine, Hannover, Germany

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  2. William S. Blaner

    1. Department of Medicine Division of Preventive Medicine & Nutrition, College of Physicians and Surgeons of Columbia University, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  • This volume provides a state-of-the-art account of recent advances in retinoid research with major emphasis on metabolism, actions and pharmacologic aspects

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 139)

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XXVIII
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  2. Metabolism, Pharmocokinetics and Action of Retinoids

    1. Front Matter

      Pages 1-1
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    2. Physical-Chemical Properties and Action of Retinoids

      • N. Noy
      Pages 3-29

    3. Biosynthesis, Absorption, Metabolism and Transport of Retinoids

      • S. Vogel, M. V. Gamble, W. S. Blaner
      Pages 31-95

    4. Retro-Retinoids: Metabolism and Action

      • E. Vakiani, J. Buck
      Pages 97-115

    5. Retinoic Acid Synthesis and Metabolism

      • W. S. Blaner, R. Piantedosi, A. Sykes, S. Vogel
      Pages 117-149

  3. Binding Proteins and Nuclear Receptors

    1. Front Matter

      Pages 151-151
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    2. Nuclear Retinoid Receptors and Mechanisms of Action

      • F. Javier Piedrafita, M. Pfahl
      Pages 153-184

    3. RAR-Selective Ligands: Receptor Subtype and Function Selectivity

      • R. L. Beard, R. A. S. Chandraratna
      Pages 185-213

    4. RXR-Specific Agonists and Modulators: A New Retinoid Pharmacology

      • I. G. Schulman, D. Crombie, R. P. Bissonnette, R. Cesario, K. Roegner, G. Shao et al.
      Pages 215-235

  4. Differentiation, Proliferation, and Cancer

    1. Front Matter

      Pages 237-237
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    2. Growth Control by Retinoids: Regulation of Cell Cycle Progression and Apoptosis

      • B. Harvat, A. M. Jetten
      Pages 239-276

    3. Retinoids and Differentiation of Normal and Malignant Hematopoietic Cells

      • A. Agadir, C. Chomienne
      Pages 277-300

    4. The Retinoids: Cancer Therapy and Prevention Mechanisms

      • K. Nason-Burchenal, E. Dmitrovsky
      Pages 301-322

    5. Aberrant Expression and Function of Retinoid Receptors in Cancer

      • X.-C. Xu, R. Lotan
      Pages 323-343
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Keywords

About this book

In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re­ cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper­ imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.

Editors and Affiliations

  • Department of Food Toxicology Center of Food Science, School of Veterinary Medicine, Hannover, Germany

    Heinz Nau

  • Department of Medicine Division of Preventive Medicine & Nutrition, College of Physicians and Surgeons of Columbia University, New York, USA

    William S. Blaner

Bibliographic Information

  • Book Title: Retinoids

  • Book Subtitle: The Biochemical and Molecular Basis of Vitamin A and Retinoid Action

  • Editors: Heinz Nau, William S. Blaner

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-58483-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1999

  • Hardcover ISBN: 978-3-540-65892-4Published: 06 September 1999

  • Softcover ISBN: 978-3-642-63614-1Published: 09 October 2012

  • eBook ISBN: 978-3-642-58483-1Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXVIII, 619

  • Number of Illustrations: 73 b/w illustrations, 6 illustrations in colour

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Molecular Medicine, Cancer Research, Dermatology

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