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The Peroxidase Multigene Family of Enzymes

Biochemical Basis and Clinical Applications

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. Petro E. Petrides

    1. Department of Medicine, Charité Humboldt University of Berlin, Berlin, Germany

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  2. William M. Nauseef

    1. Inflammation Program and Departments of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 papers)

  1. Front Matter

    Pages I-XII
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  2. Peroxidases: A Historical Overview of Milestones in Research on Myeloperoxidase

    • Robert A. Clark
    Pages 1-10

  3. Targeting of Proteins to Lysosomes and Granules

    • Andrej Hasilik
    Pages 11-21

  4. Sorting and Processing of Neutrophil Granule Proteins

    • Urban Gullberg, Niklas Bengtsson, Elinor Bülow, Daniel Garwicz, Anders Lindmark, Inge Olsson
    Pages 22-30

  5. X-Ray Crystallographic Studies of Human Myeloperoxidase

    • C. A. Davey, T. Fiedler, R. E. Fenna
    Pages 31-37

  6. Structural and Biological Properties of Human Recombinant Myeloperoxidase

    • Nicole Moguilevsky, Alex Bollen
    Pages 38-44

  7. Recent Insights into the Biosynthesis and Processing of Human Myeloperoxidase

    • William M. Nauseef
    Pages 45-51

  8. Targets for Myeloperoxidase-Dependent Bactericidal Activity

    • Henry Rosen
    Pages 52-57

  9. Reactions of Myeloperoxidase and Production of Hypochlorous Acid in Neutrophil Phagosomes

    • Christine C. Winterbourn, Christine J. van Dalen, Mark B. Hampton, Anthony J. Kettle
    Pages 58-67

  10. Acquisition and Use of Myeloperoxidase in the Microbicidal Activity of Macrophages

    • Laszlo Marodi, Christopher Tourney, Rita Kaposzta, Richard B. Johnston Jr., Nicole Moguilevsky
    Pages 68-71

  11. Cooperative Interactions of the Peroxidase and Nitric Oxide Pathways in Inflammatory Oxidant Production

    • Jason P. Eiserich, Bruce A. Freeman, Carroll E. Cross, Albert van der Vliet
    Pages 72-85

  12. The Role of the Monoclonal Antibody Anti-Myeloperoxidase (anti-MPO) in the Diagnosis and Classification of Acute Leukaemias

    • Estella Matutes
    Pages 86-92

  13. The Role of Myeloperoxidase in Myeloid Leukemia and Multiple Sclerosis

    • Wanda F. Reynolds
    Pages 93-101

  14. Pathways for Oxidative Tissue Injury by Myeloperoxidase

    • Jay W. Heinecke
    Pages 102-106

  15. Myeloperoxidase Activity of Neutrophils in Cystic Fibrosis

    • Véronique Witko-Sarsat
    Pages 107-113

  16. Structure Function Relationships Amongst Members of the Animal Peroxidase Family of Proteins

    • Rosa Pia Ferrari, Silvio Traversa
    Pages 114-121

  17. Myeloperoxidase (MPO) and Eosinophil Peroxidase (EPO) Deficiency in the Region Friuli-Venezia Giulia of North-Eastern Italy

    • Pierluigi Patriarca, Maurizio Romano
    Pages 122-128

  18. Biochemistry and Physiology of Thyroid Peroxidase

    • Jan J. M. de Vijlder, Hennie Bikker
    Pages 129-132

  19. Severe Congenital Hypothyroidism Caused by Mutations in the Thyroid Peroxidase Gene

    • Hennie Bikker, Jan J. M. de Vijlder
    Pages 133-135

  20. Screening for Leukocyte Peroxidase Deficiencies by Means of Flow Cytometry: Application to the Study of Prevalence, Pathology and Genetics

    • Dolphe Kutter, Luc Verstraeten
    Pages 136-144
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Keywords

About this book

In September 1998 experts from 19 countries came together for an interdisciplinary discussion of the function of animal peroxidases, a family of enzymes embracing myeloperoxidase, eosinophil peroxidase, thyroid peroxidase and lactoperoxidase. Their papers have been updated for publication, yielding a wide-ranging overview of the state of the art. The chapters cover a wide range of topics, including three-dimensional structure of representative family members, their biosynthesis and intracellular transport, mechanism of action as well as applications to clinical medicine. They are of clinical relevance in, for example, arteriosclerosis, multiple sclerosis, infections, tumorigenesis, rheumatic diseases and hypothyroidism. This book forms an excellent introduction for anyone interested in the peroxidase family of enzymes.

Editors and Affiliations

  • Department of Medicine, Charité Humboldt University of Berlin, Berlin, Germany

    Petro E. Petrides

  • Inflammation Program and Departments of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, USA

    William M. Nauseef

Bibliographic Information

  • Book Title: The Peroxidase Multigene Family of Enzymes

  • Book Subtitle: Biochemical Basis and Clinical Applications

  • Editors: Petro E. Petrides, William M. Nauseef

  • DOI: https://doi.org/10.1007/978-3-642-58314-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-67154-1Published: 04 August 2000

  • Softcover ISBN: 978-3-642-63535-9Published: 26 November 2012

  • eBook ISBN: 978-3-642-58314-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 193

  • Topics: Hematology, Endocrinology, Oncology

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