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Catalytic RNA

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  • © 1997
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Overview

Editors:
  1. Fritz Eckstein

    1. Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. David M. J. Lilley

    1. Biochemistry Department, University of Dundee, Dundee, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 10)

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Table of contents (22 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Group I Ribozymes: Substrate Recognition, Catalytic Strategies, and Comparative Mechanistic Analysis

    • T. R. Cech, D. Herschlag
    Pages 1-17
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  3. Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods

    • D. H. Turner, Y. Li, M. Fountain, L. Profenno, P. C. Bevilacqua
    Pages 19-32
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  4. The Structure of Group I Ribozymes

    • L. Jaeger, F. Michel, E. Westhof
    Pages 33-51
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  5. Interaction of Aminoglycoside Antibiotics with RNA

    • R. Schroeder, U. von Ahsen
    Pages 53-74
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  6. Catalytic Reaction Mechanisms and Structural Features of Group II Intron Ribozymes

    • A. M. Pyle
    Pages 75-107
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  7. Structural Analysis of the Bacterial Ribonuclease P RNA

    • J. M. Nolan, N. R. Pace
    Pages 109-128
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  8. Structural Analysis and Modifications of the Hairpin Ribozyme

    • J. M. Burke, S. E. Butcher, B. Sargueil
    Pages 129-143
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  9. Circular RNAs: Generation of Small RNAs with Unique Properties by Splicing Permuted Intron-Exon Sequences

    • M. D. Been, M. Puttaraju
    Pages 145-159
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  10. Three-Dimensional Structure of the Hammerhead Ribozyme

    • D. B. McKay
    Pages 161-172
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  11. The Hammerhead Ribozyme

    • J. B. Thomson, T. Tuschl, F. Eckstein
    Pages 173-196
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  12. Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes

    • R. G. Kuimelis, L. W. McLaughlin
    Pages 197-215
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  13. Mechanistic Studies on Hammerhead Ribozymes

    • P. K. R. Kumar, D. M. Zhou, K. Yoshinari, K. Taira
    Pages 217-230
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  14. Hammerhead Ribozymes with Long Flanking Sequences: a Structural and Kinetic View

    • G. Sczakiel
    Pages 231-242
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  15. Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes

    • N. Usman, D. T. Stinchcomb
    Pages 243-264
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  16. Synthetic Catalytic Oligonucleotides Based on the Hammerhead Ribozyme

    • B. S. Sproat
    Pages 265-281
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  17. Efficacy of Hammerhead Ribozymes Targeting α-Lactalbumin Transcripts: Experiments in Cells and Transgenic Mice

    • P. J. L’Huillier
    Pages 283-300
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  18. Anti-HIV Therapeutic Hammerhead Ribozymes: Targeting Strategies and Optimization of Intracellular Function

    • E. Bertrand, J. Rossi
    Pages 301-313
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  19. Inhibition of HIV Replication by the Hairpin Ribozyme

    • P. J. Welch, A. Hampel, J. Barber, F. Wong-Staal, M. Yu
    Pages 315-327
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  20. The Use of Ribozymes to Inhibit HIV Replication

    • L.-Q. Sun, W. L. Gerlach, G. Symonds
    Pages 329-342
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Keywords

About this book

In recent years, unprecedented advances in many aspects of the molecular biology of nucleic acids have been witnessed. The area of RNA chemistry has undergone a kind of explosion, with a huge interest in RNA-mediated catalysis. At the same time, our structural understanding of DNA-protein interactions has increased enormously, and the related area of RNA-protein interactions is beginning to gather pace. This softcover edition from the successful series Nucleic Acids and Molecular Biology is devoted to the structure and mechanism of ribozymes, and their potential exploitation. The subject has both important evolutionary implications and potential practical application in the development of therapeutic agents for diseases such as AIDS.

Reviews

"This collection will provide a valuable resource to beginning investigators and to the general scientist who has kept abreast of the field to date." Cell
"This volume is a rich source of information on catalytic RNA, with many of the major players contributing articles." Nature

Editors and Affiliations

  • Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

    Fritz Eckstein

  • Biochemistry Department, University of Dundee, Dundee, UK

    David M. J. Lilley

Bibliographic Information

  • Book Title: Catalytic RNA

  • Editors: Fritz Eckstein, David M. J. Lilley

  • Series Title: Nucleic Acids and Molecular Biology

  • DOI: https://doi.org/10.1007/978-3-642-61202-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-540-62679-4Published: 09 April 1997

  • eBook ISBN: 978-3-642-61202-2Published: 06 December 2012

  • Series ISSN: 0933-1891

  • Series E-ISSN: 1869-2486

  • Edition Number: 1

  • Number of Pages: XIV, 418

  • Number of Illustrations: 18 b/w illustrations, 11 illustrations in colour

  • Topics: Cell Biology, Biochemistry, general

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