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Clinical Pharmacology in the Elderly

Reference Ranges and Biological Variations After Repeated Measurements

  • Book
  • © 1996

Overview

Authors:
  1. Hans-Peter Breuel

    1. Pharmacon Research, Gesellschaft für Arzneimittelforschung mbH, Berlin, Germany

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Introduction

    • Hans-Peter Breuel
    Pages 1-2

  3. Theories of Aging

    • Hans-Peter Breuel
    Pages 3-3

  4. Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age

    • Hans-Peter Breuel
    Pages 5-28

  5. Practical Aspects in Performing Clinical Trials in Elderly Subjects

    • Hans-Peter Breuel
    Pages 29-33

  6. Experimental Findings in Elderly Subjects

    • Hans-Peter Breuel
    Pages 35-87

  7. Statistical Details

    • Hans-Peter Breuel
    Pages 89-168

  8. Back Matter

    Pages 169-182
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Keywords

About this book

The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma­ cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude .... :''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.

Authors and Affiliations

  • Pharmacon Research, Gesellschaft für Arzneimittelforschung mbH, Berlin, Germany

    Hans-Peter Breuel

Bibliographic Information

  • Book Title: Clinical Pharmacology in the Elderly

  • Book Subtitle: Reference Ranges and Biological Variations After Repeated Measurements

  • Authors: Hans-Peter Breuel

  • DOI: https://doi.org/10.1007/978-3-642-60998-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-540-59495-6Published: 01 December 1995

  • eBook ISBN: 978-3-642-60998-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 182

  • Number of Illustrations: 2 b/w illustrations

  • Topics: Pharmacology/Toxicology, Internal Medicine

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