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Pharmacological Aspects of Drug Dependence

Toward an Integrated Neurobehavioral Approach

  • Book
  • © 1996

Overview

Editors:
  1. Charles R. Schuster

    1. University Psychiatric Center, Wayne State University School of Medicine, Detroit, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael J. Kuhar

    1. Director, The National Institute on Drug Abuse, Addiction Research Center, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 118)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XXV
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  2. Research in the Study of Drug Action and Addiction

    1. Front Matter

      Pages 1-1
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    2. Genetic Vulnerability to Substance Abuse

      • R. W. Pickens, G. I. Elmer, M. C. LaBuda, G. R. Uhl
      Pages 3-52

    3. Integrative Neurobehavioral Pharmacology: Focus on Cocaine

      • M. J. Kuhar, C. R. Schuster
      Pages 53-80

  3. Molecular, Behavioral, and Human Pharmacology of Dependence and Consequences

    1. Front Matter

      Pages 81-81
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    2. Marihuana

      • D. R. Compton, L. S. Harris, A. H. Lichtman, B. R. Martin
      Pages 83-158

    3. Cocaine

      • M. W. Fischman, C.-E. Johanson
      Pages 159-195

    4. Opioid Analgesics

      • L. Dykstra
      Pages 197-232

    5. Phencyclidine: A Drug of Abuse and a Tool for Neuroscience Research

      • R. L. Balster, J. Willetts
      Pages 233-262

    6. Benzodiazepine Discontinuation Syndromes: Clinical and Experimental Aspects

      • L. G. Miller, D. J. Greenblatt
      Pages 263-269

    7. Nicotine

      • J. E. Henningfield, R. M. Keenan, P. B. S. Clarke
      Pages 271-314

    8. Caffeine Reinforcement, Discrimination, Tolerance and Physical Dependence in Laboratory Animals and Humans

      • R. R. Griffiths, G. K. Mumford
      Pages 315-341

    9. Classical Hallucinogens

      • R. A. Glennon
      Pages 343-371

    10. Alcohol

      • B. Tabakoff, K. Hellevuo, P. L. Hoffman
      Pages 373-458
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Keywords

About this book

In spite of a "war on drugs" that spans years, and in spite of increases in law enforcement efforts and to a lesser extent treatment, substance abuse and dependence continue. While the number of people who experiment with drugs has decreased in recent years, those who use drugs repeatedly, per­ haps several times a week, a measure of "hard core" drug abusers, has not changed, and emergency room visits associated with substances abuse continues to rise. Considering both licit and illicit drug abuse, the number of drug abusers in, for example, the United States is very large and, accordingly, the cost to society is great. A recent Institute of Medicine study suggests that the overall cost is about $66 billion per year (1990 costs). Certainly when assessing the total cost of substance abuse, we must include of the costs of disease and behavioral disorders that are intimately associated with substance abuse. For example, sharing of needles among illicit drug abusers has been and is a critical vector in the spread of drug resistant TB, AIDS, and hepatitis. Further, the use of drugs and alcohol leads to unsafe sexual practices with the attendant risk of AIDS and other sexually transmitted diseases. Tragically, infants are born with drugs in their system and with infections and disease transmitted from the mothers who are drug abusers or their sex partners who are drug abusers.

Editors and Affiliations

  • University Psychiatric Center, Wayne State University School of Medicine, Detroit, USA

    Charles R. Schuster

  • Director, The National Institute on Drug Abuse, Addiction Research Center, Baltimore, USA

    Michael J. Kuhar

Bibliographic Information

  • Book Title: Pharmacological Aspects of Drug Dependence

  • Book Subtitle: Toward an Integrated Neurobehavioral Approach

  • Editors: Charles R. Schuster, Michael J. Kuhar

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-60963-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-64631-7Published: 16 September 2011

  • eBook ISBN: 978-3-642-60963-3Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXV, 658

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Internal Medicine

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