Immunopathogenesis of HIV Infection

1. Front Matter

   Pages I-VIII

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2. Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection

   • Guiseppe Pantaleo, Anthony S. Fauci

   Pages 1-4

3. Virologic and immunologic events in primary HIV infection

   • Guiseppe Pantaleo, Cecilia Graziosi, Anthony S. Fauci

   Pages 5-14

4. The role of viral dynamics in the pathogenesis of HIV disease and implications for antiviral therapy

   • Diane V. Havlir, Douglas D. Richman

   Pages 15-31

5. Immune dysregulation and CD4+ T cell loss in HIV-1 infection

   • Linde Meyaard, Frank Miedema

   Pages 33-51

6. Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies

   • Oren J. Cohen, Giuseppe Pantaleo, Gordon K. Lam, Anthony S. Fauci

   Pages 53-70

7. Mechanisms of resistance to HIV infection

   • William A. Paxton, Richard A. Koup

   Pages 71-88

8. HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication

   • Christian Jassoy, Bruce D. Walker

   Pages 89-102

9. Noncytolytic CD8 T cell-mediated suppression of HIV replication

   • Michael L. Greenberg, Simon F. Lacey, Chin-Ho Chen, Dani P. Bolognesi, Kent J. Weinhold

   Pages 103-117

10. Role of complement and Fc receptors in the pathogenesis of HIV-1 infection

    • David C. Montefiori

    Pages 119-138

11. Simian immunodeficiency virus as a model of HIV pathogenesis

    • Stephen Norley, Reinhard Kurth

    Pages 139-153

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.

• HIV
• T cell
• cell
• immunodeficiency
• infection
• lymphocytes
• pathogenesis
• resistance
• virus

• Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

  Anthony S. Fauci

• Laboratory of AIDS Immunopathogenesis Department of Medicine Division of Infectious Diseases, Centre Hospitalier Universitaire Vadois (CHUV), Lausanne, Switzerland

  Giuseppe Pantaleo

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