C-Myc in B-Cell Neoplasia

1. Front Matter

   Pages I-XII

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2. The c-myc Story: Where we’ve been, Where we seem to be Going

   1. The c-myc Story: Where we’ve been, Where we seem to be Going

      • M. Potter, K. B. Marcu

      Pages 1-17

3. B-lymphocyte-lineage Cells from Early Precursors to Ig-secreting Plasma Cells: Targets of Regulation by the myc/mad/max Families of Genes?

   1. B-lymphocyte-lineage Cells from Early Precursors to Ig-secreting Plasma Cells: Targets of Regulation by the myc/mad/max Families of Genes?

      • F. Melchers

      Pages 19-30

4. Regulation of the C-Myc Gene

   1. Front Matter

      Pages 31-31

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   2. DNA Conformation, Topology, and the Regulation of c-myc Expression

      • D. Levens, R. C. Duncan, T. Tomonaga, G. A. Michelotti, I. Collins, T. Davis-Smyth et al.

      Pages 33-46

   3. Differential Regulation of the c-MYC P1 and P2 Promoters in the Absence of Functional Tumor Suppressors: Implications for Mechanisms of Deregulated MYC Transcription

      • K. B. Marcu, A. J. Patel, Y. Yang

      Pages 47-56

   4. Positive and Negative Regulation of c-Myc Transcription

      • X. Zou, Y. Lin, S. Rudchenko, K. Calame

      Pages 57-66

   5. Structure and Expression of the c-Myc/Pvt 1 Megagene Locus

      • D. Siwarski, U. Müller, J. Andersson, V. Notario, F. Melchers, A. Rolink et al.

      Pages 67-72

   6. Murine and Human 3′ IgH Regulatory Sequences

      • B. K. Birshtein, C. Chen, S. Saleque, J. S. Michaelson, M. Singh, R. D. Little

      Pages 73-80

5. Negative Regulation of C-Myc

   1. Front Matter

      Pages 81-81

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   2. Receptor-specific Regulation of NF-κB, c-Myc and Fas-mediated Apoptosis in Primary B Cells

      • D. A. Francis, R. Sen, T. L. Rothstein

      Pages 83-90

   3. c-Myc Promotes Survival of WEHI 231 B Lymphoma Cells from Apoptosis

      • M. Wu, W. Yang, R. E. Bellas, S. L. Schauer, M. J. FitzGerald, H. Lee et al.

      Pages 91-101

   4. Role of c-myc and p27 in Anti-IgM Induced B-Lymphoma Apoptosis

      • D. W. Scott, D. Donjerković, B. Maddox, S. Ezhevsky, T. Grdina

      Pages 103-111

6. C-Myc Protein Interactions

   1. Front Matter

      Pages 113-113

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   2. Mnt: A Novel Max-interacting Protein and Myc Antagonist

      • P. J. Hurlin, C. Qúeva, R. N. Eisenman

      Pages 115-121

   3. Regulation of Cell Growth by the Myc-Max-Mad Network: Role of Mad Proteins and YY1

      • M. Austen, C. Cerni, M. Henriksson, S. Hilfenhaus, J. M. Lüscher-Firzlaff, A. Menkel et al.

      Pages 123-130

   4. C-Myc Transrepression and Cell Transformation

      • L. A. Lee, C. V. Dang

      Pages 131-135

   5. Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc

      • A. Schneider, K. Peukert, M. Eilers, F. Hänel

      Pages 137-146

7. C-Myc Protein Interactions: Max, Mad, Mxil

   1. Front Matter

      Pages 147-147

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   2. Regulated Expression and Function of the c-Myc Antagonist, Mad1, During a Molecular Switch from Proliferation to Differentiation

      • C. M. Cultraro, T. Bino, S. Segal

      Pages 149-158

The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre­ sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi­ torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.

• DNA
• apoptosis
• cell
• cytokine
• growth
• immunoglobulin
• interferon
• lymphoma
• pathogenesis
• protein
• proteins
• tumor

• Laboratory of Genetics, Building 37, Room 2B04, National Cancer Institute, National Institutes of Health, Bethesda, USA

  Michael Potter

• Basel Institute for Immunology, Basel, Switzerland

  Fritz Melchers

Policies and ethics