Mechanisms of Transcription

1. Front Matter

   Pages I-XI

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2. Fundamental Aspects of T7 RNA Polymerase Structure and Mechanism

   • R. Sousa

   Pages 1-14

3. Transcription by T7 RNA Polymerase

   • W. T. McAllister

   Pages 15-25

4. Pribnow Box Recognition and Melting by Escherichia coli RNA Polymerase

   • S. A. Darst, J. W. Roberts, A. Malhotra, M. Marr, K. Severinov, E. Severinova

   Pages 27-40

5. Extended —10 Promoters

   • J. A. Bown, K. A. Barne, S. D. Minchin, S. J. W. Busby

   Pages 41-52

6. Promoter Selectivity Control of RNA Polymerase

   • A. Ishihama

   Pages 53-70

7. The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase

   • L. Erijman, R. M. Clegg

   Pages 71-86

8. Ribosomal RNA Promoter-RNA Polymerase Interactions and rRNA Transcription in Escherichia coli

   • T. Gaal, W. Ross, R. L. Gourse

   Pages 87-100

9. Synergistic Activation of Transcription in E. coli

   • A. Hochschild, J. K. Joung

   Pages 101-114

10. Indirect Effects of DNA Sequence on Transcriptional Activation by Prokaryotic DNA Binding Proteins

    • S. Hilchey, J. Xu, G. B. Koudelka

    Pages 115-134

11. Transcriptional Activation by a Topologically Linkable Protein: Forging a Connection Between Replication and Gene Activity

    • E. P. Geiduschek, T.-J. Fu, G. A. Kassavetis, G. M. Sanders, R. L. Tinker-Kulberg

    Pages 135-150

12. Translocation of DNA-Dependent E. coli RNA Polymerase During RNA Synthesis

    • H. Heumann, E. Zaychikov, L. Denissova, T. Hermann

    Pages 151-177

13. Stabilization of DNA Microloops by FIS — A Mechanism for Torsional Transmission in Transcription Activation and DNA Inversion

    • G. Muskhelishvili, A. Travers

    Pages 179-190

14. Transcription and DNA Topology in Eubacteria

    • D. M. J. Lilley

    Pages 191-217

15. Modeling Large DNA Molecules: Long-Range Interactions and Regulation of Transcription

    • J. Langowski

    Pages 219-235

16. Structure of the POU Domain

    • M. M. Cox, R. Boelens, P. C. Van der Vliet, R. Kaptein

    Pages 237-250

17. Structural Studies of Eukaryotic Transcription Initiation

    • S. K. Burley

    Pages 251-264

18. Understanding SRY-Related 46X,Y Sex Reversal at the Atomic Level

    • G. M. Clore, M. H. Werner, J. R. Huth, A. M. Gronenborn

    Pages 265-273

19. Nucleosomes and Transcription

    • A. P. Wolffe, K. P. Nightingale, K. Ura

    Pages 275-290

20. Antirepression, Potentiation and Activation of Promoters in Reconstituted Chromatin

    • R. Sandaltzopoulos, P. B. Becker

    Pages 291-307

Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. This includes RNA polymerase function and its interaction with promoter sequences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.

• DNA
• Escherichia coli
• Promoter
• RNA
• biochemistry
• biology
• chemistry
• developmental biology
• gene
• gene expression
• molecular biology
• protein
• structural biology
• synthesis
• transcription

"The editors are to be congratulated in assembling an excellent collection of contributions from very eminent authors. This book will make a splendid addition to the shelves of those interested in the biophysics, biochemistry and structural biology of transcription and its regulation." Heredity

• Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

  Fritz Eckstein

• Biochemistry Department, University of Dundee, Dundee, UK

  David M. J. Lilley

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