Overview
- Editors:
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Jürg P. Seiler
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Interkantonale Kontrollstelle für Heilmittel, Switzerland
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Eugenio Vilanova
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Dept. of Neurochemistry Campus San Juan, University of Alicante, Alicante, Spain
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Table of contents (39 papers)
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The Gerhard Zbinden Memorial Lecture
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Detection of Chemically-Induced Changes in P53 Expression
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- Bertram Opalka, Sabine Kasimir-Bauer
Pages 17-28
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Norman Aldridge Memorial Symposium
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- A. Gómez de la Cámara, I. Abaitua Borda, M. Posada de la Paz
Pages 31-40
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- Rossanne M. Philen, Manuel Posada de la Paz, Robert H. Hill, Helen H. Schurz, Ignacio Abaitua Borda, Agustín Gómez de la Cámara et al.
Pages 41-52
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- Helen H. Schurz, Robert H. Hill, Rossanne M. Philen, Manuel Posada de la Paz, Ignacio Abaitua Borda, Edwin M. Kilbourne et al.
Pages 53-64
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- Carlos Lahoz, Victoria del Pozo, Soledad Gallardo, Blanca Cárdaba, Aurora Jurado, Isabel Cortegano et al.
Pages 65-73
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Altered Gene Expression and Immunotoxicity
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- Diels J. van den Dobbelsteen, C. Stefan I. Nobel, Andrew F. G. Slater, Sten Orrenius
Pages 77-85
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- Nathalie Auphan, Joseph A. Didonato, Arno Helmberg, Caridad Rosette, Michael Karin
Pages 87-95
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- Johan Garssen, Rob J. Vandebriel, Henk van Loveren
Pages 97-109
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The Use of Ecotoxicology and Human Toxicology in the Regulation of Chemical Safety in the European Union
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Front Matter
Pages 111-111
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- Michael Matthies, Frank Koormann, Geert Boeije, Tom CJ Feijtel
Pages 123-135
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About this book
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Editors and Affiliations
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Interkantonale Kontrollstelle für Heilmittel, Switzerland
Jürg P. Seiler
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Dept. of Neurochemistry Campus San Juan, University of Alicante, Alicante, Spain
Eugenio Vilanova