Connections, Cognition and Alzheimer’s Disease

1. Front Matter

   Pages I-XIII

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2. Aspects of Cortical Destruction in Alzheimer’s Disease

   • H. Braak, E. Braak

   Pages 1-16

3. Cortical Feedforward and Cortical Feedback Neural Systems in Alzheimer’s Disease

   • G. W. Van Hoesen

   Pages 17-31

4. Plaques and Tangles: Where and When?

   • C. Duyckaerts, M.-A. Colle, M. Bennecib, Y. Grignon, T. Uchihara, J.-J. Hauw

   Pages 33-39

5. Cortical Mapping of Pathological Tau Proteins in Several Neurodegenerative Disorders

   • P. Vermersch, V. Buée-Scherrer, L. Buée, J. P. David, A. Wattez, N. Sergeant et al.

   Pages 41-52

6. Neurofibrillary Tangles are Associated with the Differential Loss of Message Expression for Synaptic Proteins in Alzheimer’s Disease

   • Linda Callahan, Paul D. Coleman

   Pages 53-57

7. Morphologic and Neurochemical Characteristics of Corticocortical Projections: Emergence of Circuit-specific Features and Relationships to Degenerative Changes in Alzheimer’s Disease

   • P. R. Hof, E. A. Nimchinsky, L. G. Ungerleider, J. H. Morrison

   Pages 59-82

8. Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease

   • D. F. Swaab, P. J. Lucassen, J. A. P. van de Nes, R. Ravid, A. Salehi

   Pages 83-104

9. Neurodegenerative Alzheimer-like Pathology in PDAPP 717V → F Transgenic Mice

   • D. Games, E. Masliah, M. Lee, K. Johnson-Wood, D. Schenk

   Pages 105-119

10. Molecular Mechanisms of Synaptic Disconnection in Alzheimer’s Disease

    • E. Masliah, M. Mallory, M. Alford, R. DeTeresa, A. Iwai, T. Saitoh

    Pages 121-140

11. Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus

    • M. J. West, P. D. Coleman, D. G. Flood, J. C. Troncoso

    Pages 141-147

12. Connections and Cognitive Impairment in Alzheimer’s Disease

    • T. Gomez-Isla, B. T. Hyman

    Pages 149-166

13. Distributed Hierarchical Neural Systems for Visual Memory in Human Cortex

    • J. V. Haxby, V. P. Clark, M. Courtney

    Pages 167-180

14. Language and the Alzheimer Brain

    • A. R. Damasio, H. Damasio

    Pages 181-189

15. Back Matter

    Pages 191-193

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The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. Are neurofibrillary tangles and senile plaques directly related to clinical symptoms, or are they epiphenomena that signal synaptic and neuronal loss? In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation Ipsen which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology. .

• Alzheimer's disease
• Alzheimer´s disease
• aging
• brain
• cognition
• cortex
• cortical destruction
• cortical feedback
• dementia
• neural system
• neurodegenerative disorders
• synaptic disconnection

• Nuerology Service, Massachusetts General Hospital, Boston, USA

  B. T. Hayman

• Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Paris Cedex 16, France

  C. Duyckaerts

• Fondation IPSEN, Paris Cedex 16, France

  Y. Christen

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