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Chromosomal Translocations and Oncogenic Transcription Factors

  • Book
  • © 1997

Overview

Editors:
  1. Frank J. Rauscher

    1. The Wistar Institute, Philadelphia, USA

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  2. Peter K. Vogt

    1. Division of Oncovirology, BCC 239 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 220)

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Table of contents (10 chapters)

  1. Front Matter

    Pages I-XI
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  2. Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications

    • P. M. Waring, M. L. Cleary
    Pages 1-23

  3. E2A-Pbx1 Induces Growth, Blocks Differentiation, and Interacts with Other Homeodomain Proteins Regulating Normal Differentiation

    • M. P. Kamps
    Pages 25-43

  4. E2A-HLF Chimeric Transcription Factors in Pro-B Cell Acute Lymphoblastic Leukemia

    • A. T. Look
    Pages 45-53

  5. Transcription Factors of the bHLH and LIM Families: Synergistic Mediators of T Cell Acute Leukemia?

    • R. Baer, L.-Y. Hwang, R. O. Bash
    Pages 55-65

  6. The TEL Gene Contributes to the Pathogenesis of Myeloid and Lymphoid Leukemias by Diverse Molecular Genetic Mechanisms

    • T. R. Golub, G. F. Barker, K. Stegmaier, D. G. Gilliland
    Pages 67-79

  7. Characterisation of the PML/RARα Rearrangement Associated with t(15;17) Acute Promyelocytic Leukaemia

    • D. Grimwade, E. Solomon
    Pages 81-112

  8. Fusions Involving Paired Box and Fork Head Family Transcription Factors in the Pediatric Cancer Alveolar Rhabdomyosarcoma

    • F. G. Barr
    Pages 113-129

  9. TLS-CHOP and the Role of RNA-Binding Proteins in Oncogenic Transformation

    • D. Ron
    Pages 131-142

  10. Biology of EWS/FLI and Related Fusion Genesin Ewing’s Sarcoma and Primitive Neuroectodermal Tumor

    • W. A. May, C. T. Denny
    Pages 143-150

  11. Chromosome Translocation-Mediated Conversion of a Tumor Suppressor Gene into a Dominant Oncogene: Fusion of EWS1 to WT1 in Desmoplastic Small Round Cell Tumors

    • F. J. Rauscher III
    Pages 151-162

  12. Back Matter

    Pages 163-166
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Keywords

About this book

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

Editors and Affiliations

  • The Wistar Institute, Philadelphia, USA

    Frank J. Rauscher

  • Division of Oncovirology, BCC 239 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Chromosomal Translocations and Oncogenic Transcription Factors

  • Editors: Frank J. Rauscher, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-60479-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1997

  • Softcover ISBN: 978-3-642-64424-5Published: 02 October 2011

  • eBook ISBN: 978-3-642-60479-9Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 166

  • Topics: Immunology, Virology, Cell Biology, Molecular Medicine, Cancer Research

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