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Contributions of Physiology to the Understanding of Diabetes

Ten Essays in Memory of Albert E. Renold

  • Book
  • © 1997

Overview

Editors:
  1. Gaston R. Zahnd

    1. Fondation pour Recherches Médicales Faculté de Médecine, Université de Genève, Genève 4, Switzerland

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  2. Claes B. Wollheim

    1. Division de Biochimie clinique et de Diabétologie expérimentale, Centre Médical Universitaire, Genève 4, Switzerland

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Table of contents (10 chapters)

  1. Front Matter

    Pages I-XV
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  2. Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold

    • M. Rodbell
    Pages 1-9

  3. Anabolic Response to Cell Swelling in the Liver

    • L. Hue, V. Gaussin, U. Krause
    Pages 10-23

  4. Intercellular Communication and Insulin Secretion

    • P. Meda
    Pages 24-42

  5. Expression of the Insulin Gene and Its Regulation

    • J. Philippe
    Pages 43-53

  6. Implications of the Glucokinase Glucose Sensor Paradigm for Pancreaticβ-Cell Function

    • F. M. Matschinsky
    Pages 54-67

  7. How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in theβ-Cell

    • C. B. Wollheim
    Pages 68-88

  8. The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction

    • P. De Meyts, K. Seedorf
    Pages 89-107

  9. Cell Biology of Insulin Action on Glucose Transport: Looking Back

    • S. W. Cushman
    Pages 108-126

  10. Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus

    • E. R. Froesch
    Pages 127-147

  11. On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition

    • J. Nerup, T. Mandrup-Poulsen, F. Pociot, A. E. Karlsen, H. U. Andersen, U. B. Christensen et al.
    Pages 148-159

  12. Back Matter

    Pages 160-173
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Keywords

About this book

Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ß-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.

Editors and Affiliations

  • Fondation pour Recherches Médicales Faculté de Médecine, Université de Genève, Genève 4, Switzerland

    Gaston R. Zahnd

  • Division de Biochimie clinique et de Diabétologie expérimentale, Centre Médical Universitaire, Genève 4, Switzerland

    Claes B. Wollheim

Bibliographic Information

  • Book Title: Contributions of Physiology to the Understanding of Diabetes

  • Book Subtitle: Ten Essays in Memory of Albert E. Renold

  • Editors: Gaston R. Zahnd, Claes B. Wollheim

  • DOI: https://doi.org/10.1007/978-3-642-60475-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-64422-1Published: 03 October 2013

  • eBook ISBN: 978-3-642-60475-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XV, 173

  • Number of Illustrations: 35 b/w illustrations

  • Topics: Metabolic Diseases, Human Physiology, Biochemistry, general

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