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Cytoplasmic fate of messenger RNA

  • Book
  • © 1997

Overview

Editors:
  1. Philippe Jeanteur

    1. Institut de Génétique Moléculaire, C.N.R.S., Montpellier Cedex 01, France

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Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 18)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-XV
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  2. TOP Genes: A Translationally Controlled Class of Genes Including Those Coding for Ribosomal Proteins

    • F. Amaldi, P. Pierandrei-Amaldi
    Pages 1-17

  3. RNase L: Effector Nuclease of an Activatable RNA Degradation System in Mammals

    • C. Bisbal
    Pages 19-34

  4. 3´ Untranslated Regions of c-myc and c-fos mRNAs: Multifunctional Elements Regulating mRNA Translation, Degradation and Subcellular Localization

    • J. L. Veyrune, J. Hesketh, J. M. Blanchard
    Pages 35-63

  5. Cell-Free Systems for Analysis of Cytoplasmic mRNA Turnover

    • C. T. DeMaria, G. Brewer
    Pages 65-91

  6. Mechanisms for Posttranscriptional Regulation by Iron-Responsive Elements and Iron Regulatory Proteins

    • M. Muckenthaler, M. W. Hentze
    Pages 93-115

  7. Interaction Between Iron-Regulatory Proteins and Their RNA Target Sequences, Iron-Responsive Elements

    • B. R. Henderson, L. C. Kühn
    Pages 117-139

  8. Cytoplasmic Fate of Eukaryotic mRNA: Identification and Characterization of AU-Binding Proteins

    • J. A. Jarzembowski, J. S. Malter
    Pages 141-172

  9. Translational Control by Polyadenylation During Early Development

    • H. B. Osborne, J. D. Richter
    Pages 173-198

  10. Function and Characterization of Poly(A)-Specific 3´ Exoribonucleases

    • A. Virtanen, J. Åström
    Pages 199-220

  11. Back Matter

    Pages 221-224
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Keywords

About this book

Among all cellular RNA species of the three main types, ribosomal RNA, transfer RNA or messenger RNA, be they from prokaryotic or eukaryotic organisms, the prokaryotic mRNA is unique in that it has no precursor and is synthesized in the same mature form as it is translated into proteins. In fact, ribosomes join the nascent mRNA chain and engage in protein synthesis long before its transcription is complete. Provisions are even made for slowing down the ribo­ somes at some sites to prevent them from catching up with the RNA-polymerase. Of course, such a situation is only possible in the prokaryotic world where there is no such thing as a nuclear mem­ brane physically secluding the transcription process from the cy­ toplasm where translation is restricted. Quite in the opposite extreme, the eukaryotic pre-messenger RNA has to suffer many and sometimes drastic steps of maturation (capping, polyadenylation, splicing, edition) before the decision is made to export it to the cytoplasm. That is where it enters the scope of this book. Once in the cytoplasm, many options are still open to it: its entrance into polysomes may be delayed (as it is in unfertilized eggs) or merely prohibited (ferritin mRNA in iron-starved cells), directed to specific locations within the cytoplasm or be more or less rapidly degraded. During gametogenesis and early development, translational control is probably the most significant level of gene expression.

Editors and Affiliations

  • Institut de Génétique Moléculaire, C.N.R.S., Montpellier Cedex 01, France

    Philippe Jeanteur

Bibliographic Information

  • Book Title: Cytoplasmic fate of messenger RNA

  • Editors: Philippe Jeanteur

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-642-60471-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-64420-7Published: 18 September 2011

  • eBook ISBN: 978-3-642-60471-3Published: 06 December 2012

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: XVI, 224

  • Topics: Cell Biology, Biochemistry, general

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