The Role of Immune Mechanisms in Cardiovascular Disease

1. Front Matter

   Pages I-XIX

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2. The Immunology of Myocarditis

   1. Front Matter

      Pages 1-1

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   2. Mechanisms and Genetics of Autoimmunity

      • A. N. Theofilopoulos

      Pages 3-16

   3. Molecular Pathogenesis of Myocarditis and Cardiomyopathy: Analysis of Virus-Receptor Interactions and Tyrosine Phosphorylation Events

      • H.-C. Selinka, K. Klingel, M. Huber, B. Kramer, U. Kämmerer, R. Kandolf

      Pages 17-26

   4. Coxsackievirus Genetics and the Cardiovirulent Viral Phenotype

      • N. Chapman, S. Tracy, A. Ramsingh, J. Romero, K. Curry, B. Shapiro et al.

      Pages 27-34

   5. Lessons from Animal Models of Viral Myocarditis

      • S. A. Huber, B. B. Hamrell, K. U. Knowlton

      Pages 35-43

   6. The Role of Cytokines in the Pathogenesis of Myocarditis

      • P. Liu

      Pages 44-56

   7. The Role of Heart Infiltrating Cells in Myocyte Injury

      • W. H. Barry, L. Zhao

      Pages 57-64

   8. The Significance of T Cell Responses in Human Myocarditis

      • P. Schwimmbeck, C. Badorff, K. Schulze, H.-P. Schultheiss

      Pages 65-76

   9. The Possible Pathogenic Role of Autoantibodies in Myocarditis and Dilated Cardiomyopathy

      • G. Wallukat, H.-P. Luther, J. Müller, A. Wollenberger

      Pages 77-84

   10. The Adenine Nucleotide Translocator: A Major Autoantigen in Myocarditis and Dilated Cardiomyopathy

       • H.-P. Schultheiss, K. Schulze, P. Schwimmbeck, A. Dörner

       Pages 85-100

   11. Immunohistochemical Analysis of Inflammatory Heart Disease

       • U. Kühl, M. Noutsias, H.-P. Schultheiss

       Pages 101-121

3. Immunological Mediators in Inflammation of the Heart

   1. Front Matter

      Pages 123-123

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   2. Adhesion Molecule Induction and Expression in Neutrophil-Induced Myocardial Injury

      • K. A. Youker, N. Frangogiannis, M. Lindsey, C. W. Smith, M. L. Entman

      Pages 125-137

   3. Molecular Mechanisms of Adhesion of Staphylococcus aureus to Cardiac Surfaces and Vegetations

      • C. M. Johnson

      Pages 138-144

   4. Endotoxins as Potential Mediators of Myocardial Depression

      • U. Müller-Werdan, R. Witthaut, K. Werdan

      Pages 145-156

4. Immunological Mediators in Arteriosclerosis

   1. Front Matter

      Pages 157-157

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   2. Transplant Associated Coronary Artery Disease

      • C. H. Wheeler, A. D. Collins, M. J. Dunn, S. J. Crisp, M. H. Yacoub, M. L. Rose

      Pages 159-173

   3. Role of Ischemia/Reperfusion Injury in Organ Transplantation

      • H.-A. Lehr, K. Messmer

      Pages 174-185

   4. The Role of NO Synthases in Immunological Diseases: Importance for Left Ventricular Function

      • M. Kelm, B. Yilmaz

      Pages 186-193

An involvement of the immune system is suspected in various cardiovascular diseases. Recent advances in the fields of molecular biology, genetics, cell biology, and immunology have made it possible to identify several pathomechanisms. However, still more questions arise with regard to the pathophysiology, diagnosis, and treatment of immunologically mediated cardiovascular diseases. In this book, leading scientists and clinicians from different areas of cardiology present the state-of-the-art knowledge on the involve­ ment of the immune system in myocardial and vascular diseases. In the field of myocarditis, both the virological and the immunological findings are presented, and the interactions between the virus and the immune system are discussed. Since the cellular immune system and its mediators play an important role in the inflammation by bacteria that cause endocarditis and septic shock, studies investigating the underlying pathomechanisms are de­ scribed. Another major topic in this volume is the involvement of the immune system in arteriosclerosis and coronary heart disease, which represents an important problem in clinical cardiology. The final chapter addresses the question of therapeutic options, presenting new approaches for a specific and effective therapy based on the current knowledge of immunologically mediated cardiovascular diseases.

• Antigen
• T cell
• autoimmunity
• bacteria
• cardiovascular
• cytokine
• diseases
• genetics
• heart
• inflammation
• pathogenesis
• proteins
• transplantation
• vascular disease
• virus

• Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Berlin, Germany

  Heinz-Peter Schultheiss, Peter Schwimmbeck

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