Biological Matrices and Tissue Reconstruction

1. Front Matter

   Pages I-XXIX

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2. Wound Healing

   1. Front Matter

      Pages 1-1

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   2. Wound Healing in Surgery

      • Sheng-De Ge

      Pages 3-12

   3. Influence of Collagen Membranes and Collagenous Sponge Material in the Connective Tissue Matrix During Wound Healing: An Immunohistochemical Study

      • G. E. Romanos, S. T. K. Hotz, F. Beyer, J. R. Strub

      Pages 13-19

   4. Collagen Matrix Implantation for Tissue Repair and Wound Healing: Present and Perspectives

      • Z. Ruszczak

      Pages 21-28

   5. Characterization of Biomaterials for Tissue Repair

      • Axel Stemberger, Jürgen Altmeppen, Frank Bader, Andreas Calatzis

      Pages 29-38

   6. Properties of Different Tissue Sealants

      • H. Redl, G. Schlag

      Pages 39-43

3. Gene Therapy and Growth Factors

   1. Front Matter

      Pages 45-45

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   2. Genetically Modified Fibroblasts-Fibrin-Glue-Suspension for in vivo Drug Delivery of Epidermal Growth Factor (EGF): A Surface Gene Therapy Model not only for Wounds

      • E. Tanczos, P. Kulmburg, C. H. Andree, J. Kopp, X.-Y. Jiao, L. Cao et al.

      Pages 47-52

   3. Genetically Modified Fibroblasts Induce Angiogenesis in the Rat Epigastric Island Flap

      • H.-G. Machens, J. R. Morgan, F. Berthiaume, P. Stefanovich, A. C. Berger

      Pages 53-59

   4. Stimulation of Growth and Proliferation of Human Cultured Keratinocytes by KGF-transfected Cells in vitro

      • J. Kopp, F. P. Dai, P. Kulmburg, E. Tanczos, C. Andree, X. Y. Jiao et al.

      Pages 61-65

   5. Genetically Modified Human Keratinocyte Clone Secretes EGF

      • F. Dai, K. Ying, Q. Fan, J. Kopp, Y. Xie, X. Jiao et al.

      Pages 67-82

4. Keratinocytes and Skin Reconstruction

   1. Front Matter

      Pages 83-83

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   2. Fibrin Glue as a Carrier for Cultured Human Keratinocytes versus Cultured Epidermal Skin Grafts in Athymic Mice Full-thickness Wounds

      • R. Horch, H. Bannasch, C. Andree, J. Kopp, G. B. Stark

      Pages 85-95

   3. Enhanced Expression of Integrin Receptors During Proliferation of Activated Keratinoblasts Prepared for Transplantation as Cell Suspension in Fibrinous Matrix

      • D. Reissig, Ch. Schmidt

      Pages 97-103

   4. Autologus ORS-Keratinocytes in the Therapy of Chronic Leg Ulcers

      • A. Meichlböck, S. Fleischer, I. Moll

      Pages 105-110

5. Visceral and Internal Tissues

   1. Front Matter

      Pages 111-111

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   2. Transplantation of Autologous Cultured Urothelium Cells onto a Prefabricated Capsule in Rats

      • G. Wechselberger, T. Schoeller, A. C. Roth, S. Lille, R. C. Rusell

      Pages 113-118

   3. Urothelial Cell Culture Behavior in Fibrin Glue Compared to Conventional Culture Medium

      • T. Schoeller, G. Wechselberger, S. Lyons, A. Otto, R. C. Russell

      Pages 119-124

   4. Autologouos Transplantation of Urothelium into Demucosalized Gastrointestinal Segments

      • B. M. Schaeffer, W. Back, M. D. Kramer, C. Schober, K. L. Waag, C. Lorenz

      Pages 125-134

C.A. VACANTI The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. Advances in the medical sciences have enabled physicians to restore lost functions in their patients through or­ gan transplantation, reconstructive surgery with autogenous tissue transfer, or the implantation of alloplastic materials. Although only recently termed "Tissue Engineering" [1], the use of biological andlor synthetic materials in conjunction with cells to create biologic substitutes to serve as functional tis­ sue replacements has been explored by modern scientists for several decades. The concept of generating functional tissue from an organ biopsy was de­ scribed very early in the literature: "The Lord God cast a deep sleep on the man, and while he was asleep, he took out one of his ribs and closed up its place with flesh. The Lord God then built up into a woman the rib that he had taken from the man" [2]. Review of history further reveals that, according to legend, the first homotransplantation of an entire limb was performed by Saints Damian and Cosmas, as depicted by the artist Fra Angelico.

• burns
• gene therapy
• implant
• skin
• surgery
• therapy
• transplantation

• Abt. Plastische und Handchirurgie, Chirurgische Universitätsklinik Freiburg, Freiburg, Germany

  G. Björn Stark, Raymund Horch, Eszter TÁczos

Policies and ethics