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Combinatorial Chemistry in Biology

  • Book
  • © 1999

Overview

Editors:
  1. Michael Famulok

    1. Kekule-Institut für Organische Chemie und Biochemie, Bonn, Germany

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  2. Ernst-L. Winnacker

    1. Institut für Biochemie — Genzentrum, Ludwig Maximilians Universität München, München, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Chi-Huey Wong

    1. The Scripps Research Institute, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 243)

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Table of contents (10 chapters)

  1. Front Matter

    Pages I-IX
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  2. Peptide Libraries in Cellular Immune Recognition

    • S. Uebel, K. H. Wiesmüller, G. Jung, R. Tampé
    Pages 1-21

  3. Antigen Sequence- and Library-Based Mapping of Linear and Discontinuous Protein—Protein-Interaction Sites by Spot Synthesis

    • U. Reineke, A. Kramer, J. Schneider-Mergener
    Pages 23-36

  4. The Two Hybrid Toolbox

    • W. Kolanus
    Pages 37-54

  5. Evolutionary Approaches to Protein Engineering

    • B. Steipe
    Pages 55-86

  6. Phage Display of Combinatorial Peptide and Protein Libraries and Their Applications in Biology and Chemistry

    • K. Johnsson, L. Ge
    Pages 87-105

  7. In Vitro Selection Methods for Screening of Peptide and Protein Libraries

    • J. Hanes, A. Plückthun
    Pages 107-122

  8. Aptamers as Tools in Molecular Biology and Immunology

    • M. Famulok, G. Mayer
    Pages 123-136

  9. In Vitro Selection of Nucleic Acid Enzymes

    • R. R. Breaker, M. Kurz
    Pages 137-158

  10. Dynamic Combinatorial Chemistry: Evolutionary Formation and Screening of Molecular Libraries

    • A. V. Eliseev, J. M. Lehn
    Pages 159-172

  11. Evolutionary Biotechnology — Reflections and Perspectives

    • U. Kettling, A. Koltermann, M. Eigen
    Pages 173-186

  12. Back Matter

    Pages 187-192
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Keywords

About this book

The essence of combinatorial chemistry or techniques involving "molecular diversity" is to generate enormous populations of molecules and to exploit appropriate screening techniques to isolate active components contained in these libraries. This idea has been the focus of research both in academia and in the pharmaceutical or biotechnology industry. Its developments go hand in hand with an exploding number of potential drug targets emerging from genomics and proteomics research. When the editors of Current Topics in Microbiology and Immunology encouraged us to assemble the present volume on Combinatorial Chemistry in Biology, we immediately felt that this might prove quite beneficial for the audience of this series. The field of combinatorial chemistry extends over a broad range of disciplines, from synthetic organic chemistry to biochemistry, from material sciences to cell biology. Each of these fields may have its own view on this topic, something which is reflected in a growing number of monographs and "special editions" of jour­ nals devoted to this issue or aspects thereof. The title of the present volume of Springer-Verlag's series suggests that it also has its own special focus. And, generally speaking, this is not wrong: we would even claim the special focus of this volume is on the immunologically relevant aspects of combinatorial chemistry.

Editors and Affiliations

  • Kekule-Institut für Organische Chemie und Biochemie, Bonn, Germany

    Michael Famulok

  • Institut für Biochemie — Genzentrum, Ludwig Maximilians Universität München, München, Germany

    Ernst-L. Winnacker

  • The Scripps Research Institute, La Jolla, USA

    Chi-Huey Wong

Bibliographic Information

  • Book Title: Combinatorial Chemistry in Biology

  • Editors: Michael Famulok, Ernst-L. Winnacker, Chi-Huey Wong

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-60142-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1999

  • Softcover ISBN: 978-3-642-64274-6Published: 09 October 2011

  • eBook ISBN: 978-3-642-60142-2Published: 29 June 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 189

  • Topics: Immunology, Cell Biology, Biotechnology

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