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Osteoarthritis

Clinical and Experimental Aspects

  • Book
  • © 1999

Overview

Authors:
  1. J.-Y. Reginster

    1. Department of Epidemiology and Public Health, University of Liège, Liège, Belgium

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  2. J.-P. Pelletier

    1. Osteoarthritis Research Unit, Centre de Recherche L.C. Simard Centre Hospitalier de l’Université de Montréal, Montréal, Canada

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  3. J. Martel-Pelletier

    1. Osteoarthritis Research Unit, Centre de Recherche L.C. Simard Centre Hospitalier de l’Université de Montréal, Montréal, Canada

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  4. Y. Henrotin

    1. Bone and Cartilage Metabolim Research Unit Department of Physical Medicine, Institute of Pathology (+5) University of Liège, Liège, Belgium

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  5. L. Crasborn

    1. UCB s.a. Global Marketing Allée de la Recherche 60, Brussels, Belgium

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  • Presents state of the art in research on osteoarthritis
  • Describes all clinical aspects of osteoarthritis
  • With contributions of the leading specialists in rheumatology
  • Includes supplementary material: sn.pub/extras

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Table of contents (25 chapters)

  1. Front Matter

    Pages I-XIV
    Download chapter PDF

  2. Structure and Function of Normal Human Adult Articular Cartilage

    1. Structure and Function of Normal Human Adult Articular Cartilage

      • E. J.-M. A. Thonar, K. Masuda, D. H. Manicourt, K. E. Kuettner
      Pages 1-19

  3. Epidemiology and Economic Consequences of Osteoarthritis

    1. The American Viewpoint

      • J. C. Scott, M. Lethbridge-Cejku, M. C. Hochberg
      Pages 20-38

    2. The European Viewpoint

      • X. Badia Llach
      Pages 38-52

  4. Experimental Models of Osteoarthritis

    1. In Vitro Models for the Study of Cartilage Damage and Repair

      • Y. Henrotin, J.-Y. Reginster
      Pages 53-81

    2. Animal Models of Osteoarthritis

      • K. D. Brandt
      Pages 81-100

  5. Pathophysiology of Osteoarthritis

    1. Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis

      • G. Nuki
      Pages 101-114

    2. Role of Biomechanical Factors

      • P. Ghosh
      Pages 115-133

    3. Genetic and Metabolic Aspects

      • C. J. Williams, S. A. Jimenez
      Pages 134-156

    4. Biochemical Factors in Joint Articular Tissue Degradation in Osteoarthritis

      • J. Martel-Pelletier, J. Di Battista, D. Lajeunesse
      Pages 156-187

    5. Role of Growth Factors and Cartilage Repair

      • W. B. Van Den Berg, P. M. Van Der Kraan, H. M. Van Beuningen
      Pages 188-209

    6. Role of Crystal Deposition in the Osteoarthritic Joint

      • G. M. McCarthy
      Pages 210-227

  6. Diagnosis and Monitoring of Osteoarthritis

    1. Direct Visualization of the Cartilage

      • X. Ayral, M. Dougados
      Pages 228-246

    2. Radiographic Imaging of Osteoarthritis

      • C. Buckland-Wright
      Pages 246-268

    3. Magnetic Resonance Imaging in Osteoarthritis

      • Y. Jiang, C. G. Peterfy, J. J. Zhao, D. L. White, J. A. Lynch, H. K. Genant
      Pages 268-295

    4. The Role of Molecular Markers to Monitor Breakdown and Repair

      • L. S. Lohmander
      Pages 296-311

  7. Evolution and Prognosis of Osteoarthritis

    1. Evolution and Prognosis of Osteoarthritis

      • E. Veys, G. Verbruggen
      Pages 312-330

  8. Impact of Osteoarthritis on Quality of Life

    1. Impact of Osteoarthritis on Quality of Life

      • J. Pouchot, J. Coste, F. Guillemin
      Pages 331-355

  9. Medical Management of Osteoarthritis

    1. Medical Aspects

      1. Basic Principles in Osteoarthritis Treatment
        • D. Choquette, J. P. Raynauld, E. Rich
        Pages 356-370
      2. Non-steroidal, Anti-inflammatory Drug Administration in the Treatment of Osteoarthritis
        • J. T. Dingle
        Pages 370-387
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Keywords

About this book

Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio­ chemical, biomechanical and molecular changes observed in clinical and ex­ perimental osteoarthritis are presented in this book.

Authors and Affiliations

  • Department of Epidemiology and Public Health, University of Liège, Liège, Belgium

    J.-Y. Reginster

  • Osteoarthritis Research Unit, Centre de Recherche L.C. Simard Centre Hospitalier de l’Université de Montréal, Montréal, Canada

    J.-P. Pelletier, J. Martel-Pelletier

  • Bone and Cartilage Metabolim Research Unit Department of Physical Medicine, Institute of Pathology (+5) University of Liège, Liège, Belgium

    Y. Henrotin

  • UCB s.a. Global Marketing Allée de la Recherche 60, Brussels, Belgium

    L. Crasborn

Bibliographic Information

  • Book Title: Osteoarthritis

  • Book Subtitle: Clinical and Experimental Aspects

  • Authors: J.-Y. Reginster, J.-P. Pelletier, J. Martel-Pelletier, Y. Henrotin, L. Crasborn

  • DOI: https://doi.org/10.1007/978-3-642-60026-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1999

  • Softcover ISBN: 978-3-540-65127-7Published: 26 April 1999

  • eBook ISBN: 978-3-642-60026-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 509

  • Number of Illustrations: 42 b/w illustrations, 26 illustrations in colour

  • Topics: Rheumatology, Internal Medicine, Orthopedics, Sports Medicine

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