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Vaccines

  • Book
  • © 1999

Overview

Editors:
  1. Peter Perlmann

    1. The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, Stockholm, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  2. Hans Wigzell

    1. MTC, Karolinska Institute, Stockholm, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a broad overview of how the immune system functions
  • Presents the various forms of vaccines used against important infectious diseases

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 133)

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Table of contents (19 chapters)

  1. Front Matter

    Pages I-XXV
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  2. Vaccines: Past, Present and Future

    • G. Schild, M. Corbel, P. Corran, P. Minor
    Pages 1-19

  3. Immunology of Infection

    • S. H. E. Kaufmann, J. Reimann
    Pages 21-42

  4. DNA Vaccines: Immunogenicity and Preclinical Efficacy

    • J. B. Ulmer, J. J. Donnelly, M. A. Liu
    Pages 43-55

  5. Antigen-Presentation Systems, Immunomodulators, and Immune Responses to Vaccines

    • C.-A. Siegrist, P.-H. Lambert
    Pages 57-92

  6. Vaccines Against Measles, Mumps, Rubella, and Varicella

    • E. Norrby
    Pages 93-119

  7. Hepatitis and Polio Vaccines

    • F. Schödel, P. Minor
    Pages 121-169

  8. Herpes

    • A. Vahlne, T. Bergström, B. Svennerholm
    Pages 171-200

  9. Toxin-Based Vaccines (Diphtheria, Tetanus, Pertussis)

    • R. Rappuoli, M. Pizza
    Pages 201-224

  10. Outer Membrane Protein Vaccines

    • J. Poolman
    Pages 225-248

  11. Carbohydrate-Based Bacterial Vaccines

    • J. T. Poolman, C. Laferrière, S. B. Svenson
    Pages 249-272

  12. Mycobacteria

    • R. Janssen, D. Young, J. Thole
    Pages 273-289

  13. Vaccines Against Diarrheal Diseases

    • J. Holmgren, A.-M. Svennerholm
    Pages 291-328

  14. Sexually Transmitted Diseases

    • E. G. Sandström
    Pages 329-356

  15. Designing a Vaccine Against HIV

    • A. M. Schultz
    Pages 357-396

  16. An Overview of Malaria Vaccine Development Efforts

    • S. Kumar, D. C. Kaslow, S. L. Hoffman
    Pages 397-442

  17. Antifertility Vaccines

    • V. C. Stevens
    Pages 443-461

  18. Cancer Vaccines

    • K. E. Hellström, I. Hellström
    Pages 463-478

  19. Prevention of Autoimmunity

    • A. J. Slavin, H. L. Weiner
    Pages 479-498

  20. Vaccines Against Allergies

    • L. Hellman
    Pages 499-526
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Keywords

About this book

The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the most cost-efficient of all medical interventions, successful vaccinations against many common infectious diseases. Such a success requires the isolation of the infectious agent or toxic substance, methods to grow and/or purify the relevant antigen and change it into something innocuous whilst maintaining its immunogenicity. Whereas the early vaccines could only use the enhanced resistance against infectious disease as a measure of vaccine efficacy, most modern vaccines rely upon standardized laboratory tests accepted to parallel the in vivo protective capacity to confirm the quality and potency of the respective vaccine. We are presently experiencing an explosion in the development of new and/or improved vaccines. This is largely due to a parallel rapid expansion in our knowledge of the immune system and of the detailed molecular structure and function of microorganisms. Using this knowledge it is now possible to compose vaccines of new types where only certain molecules (or parts of molecules) derived from a pathogen are included, excluding other potentially harmful ones. Whereas earlier attenuated live vaccines were created by em­ pirical means such vaccines can now be created by molecularly defined inter­ ventions in the genome of the microorganism.

Editors and Affiliations

  • The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, Stockholm, Sweden

    Peter Perlmann

  • MTC, Karolinska Institute, Stockholm, Sweden

    Hans Wigzell

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