Vaccines

1. Front Matter

   Pages I-XXV

   PDF

2. Vaccines: Past, Present and Future

   • G. Schild, M. Corbel, P. Corran, P. Minor

   Pages 1-19

3. Immunology of Infection

   • S. H. E. Kaufmann, J. Reimann

   Pages 21-42

4. DNA Vaccines: Immunogenicity and Preclinical Efficacy

   • J. B. Ulmer, J. J. Donnelly, M. A. Liu

   Pages 43-55

5. Antigen-Presentation Systems, Immunomodulators, and Immune Responses to Vaccines

   • C.-A. Siegrist, P.-H. Lambert

   Pages 57-92

6. Vaccines Against Measles, Mumps, Rubella, and Varicella

   • E. Norrby

   Pages 93-119

7. Hepatitis and Polio Vaccines

   • F. Schödel, P. Minor

   Pages 121-169

8. Herpes

   • A. Vahlne, T. Bergström, B. Svennerholm

   Pages 171-200

9. Toxin-Based Vaccines (Diphtheria, Tetanus, Pertussis)

   • R. Rappuoli, M. Pizza

   Pages 201-224

10. Outer Membrane Protein Vaccines

    • J. Poolman

    Pages 225-248

11. Carbohydrate-Based Bacterial Vaccines

    • J. T. Poolman, C. Laferrière, S. B. Svenson

    Pages 249-272

12. Mycobacteria

    • R. Janssen, D. Young, J. Thole

    Pages 273-289

13. Vaccines Against Diarrheal Diseases

    • J. Holmgren, A.-M. Svennerholm

    Pages 291-328

14. Sexually Transmitted Diseases

    • E. G. Sandström

    Pages 329-356

15. Designing a Vaccine Against HIV

    • A. M. Schultz

    Pages 357-396

16. An Overview of Malaria Vaccine Development Efforts

    • S. Kumar, D. C. Kaslow, S. L. Hoffman

    Pages 397-442

17. Antifertility Vaccines

    • V. C. Stevens

    Pages 443-461

18. Cancer Vaccines

    • K. E. Hellström, I. Hellström

    Pages 463-478

19. Prevention of Autoimmunity

    • A. J. Slavin, H. L. Weiner

    Pages 479-498

20. Vaccines Against Allergies

    • L. Hellman

    Pages 499-526

The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the most cost-efficient of all medical interventions, successful vaccinations against many common infectious diseases. Such a success requires the isolation of the infectious agent or toxic substance, methods to grow and/or purify the relevant antigen and change it into something innocuous whilst maintaining its immunogenicity. Whereas the early vaccines could only use the enhanced resistance against infectious disease as a measure of vaccine efficacy, most modern vaccines rely upon standardized laboratory tests accepted to parallel the in vivo protective capacity to confirm the quality and potency of the respective vaccine. We are presently experiencing an explosion in the development of new and/or improved vaccines. This is largely due to a parallel rapid expansion in our knowledge of the immune system and of the detailed molecular structure and function of microorganisms. Using this knowledge it is now possible to compose vaccines of new types where only certain molecules (or parts of molecules) derived from a pathogen are included, excluding other potentially harmful ones. Whereas earlier attenuated live vaccines were created by em­ pirical means such vaccines can now be created by molecularly defined inter­ ventions in the genome of the microorganism.

• Allergie
• Antigen
• Autoaggressionskrankheit
• HIV
• Krebs
• Sexually Transmitted Diseases
• Toxin
• autoimmune disease
• immunology
• infections
• infectious disease
• morbidity
• oncology
• protein
• virus

• The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, Stockholm, Sweden

  Peter Perlmann

• MTC, Karolinska Institute, Stockholm, Sweden

  Hans Wigzell

Policies and ethics