Skip to main content
SpringerLink
Log in

Immunobiology of Bacterial CpG-DNA

  • Book
  • © 2000

Overview

Editors:
  1. Hermann Wagner

    1. Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Technischen Universität München, München, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 247)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Mechanism of Action of CpG DNA

    • A. M. Krieg, G. Hartmann, A.-K. Yi
    Pages 1-21

  3. Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ Sequence Induce Production of Interferons

    • S. Yamamoto, T. Yamamoto, T. Tokunaga
    Pages 23-39

  4. Macrophage Activation by Immunostimulatory DNA

    • K. J. Stacey, D. P. Sester, M. J. Sweet, D. A. Hume
    Pages 41-58

  5. Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells

    • T. Sparwasser, G. B. Lipford
    Pages 59-75

  6. Signal Transduction Pathways Activated by CpG-DNA

    • H. Häcker
    Pages 77-92

  7. CpG DNA Co-Stimulates Antigen-Reactive T Cells

    • K. Heeg
    Pages 93-105

  8. Role of Type I Interferons in T Cell Activation Induced by CpG DNA

    • S. Sun, J. Sprent
    Pages 107-117

  9. Hematopoietic Remodeling Triggered by CpG DNA

    • G. B. Lipford, T. Sparwasser
    Pages 119-129

  10. CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines

    • D. M. Klinman, K. J. Ishii, D. Verthelyi
    Pages 131-142

  11. The Role of Bacterial DNA in Autoantibody Induction

    • D. S. Pisetsky
    Pages 143-155

  12. CpG DNA in Cancer Immunotherapy

    • G. J. Weiner
    Pages 157-170

  13. Use of CpG DNA for Enhancing Specific Immune Responses

    • H. L. Davis
    Pages 171-183

  14. Immunostimulatory-Sequence DNA is an Effective Mucosal Adjuvant

    • A. A. Horner, E. Raz
    Pages 185-198

  15. CpG DNA Switches on Th1 Immunity and Modulates Antigen-Presenting Cell Function

    • R. S. Chu, D. Askew, C. V. Harding
    Pages 199-210

  16. Effects of CpG DNA on Th1/Th2 Balance in Asthma

    • J. N. Kline
    Pages 211-225

  17. Responses of Human B Cells to DNA and Phosphorothioate Oligodeoxynucleotides

    • H. Liang, P. E. Lipsky
    Pages 227-240

  18. Back Matter

    Pages 241-248
    Download chapter PDF
Back to top

Keywords

About this book

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.

Editors and Affiliations

  • Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Technischen Universität München, München, Germany

    Hermann Wagner

Bibliographic Information

  • Book Title: Immunobiology of Bacterial CpG-DNA

  • Editors: Hermann Wagner

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-59672-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2000

  • Softcover ISBN: 978-3-642-64077-3Published: 26 September 2011

  • eBook ISBN: 978-3-642-59672-8Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 246

  • Topics: Immunology, Microbiology, Cancer Research

Publish with us

Policies and ethics

Back to top

Search

Navigation