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Toll-Like Receptor Family Members and Their Ligands

  • Book
  • © 2002

Overview

Editors:
  1. Bruce Beutler

    1. Department of Immunology, The Scripps Research Institute, La Jolla, USA

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  2. Hermann Wagner

    1. Institut für Medizinische Mikrobiologie, Immunologie and Hygiene Technische Universität München, München, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First book describing the sensing mechanism of the innate immune system.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 270)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-IX
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  2. Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology

    • B. Beutler, M. Rehli
    Pages 1-21

  3. Plant Disease Resistance: Commonality and Novelty in Multicellular Innate Immunity

    • R. Fluhr, R. N. Kaplan-Levy
    Pages 23-46

  4. Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor Superfamily

    • L. A. J. O’Neill
    Pages 47-61

  5. Toll Receptors in Drosophila: a Family of Molecules Regulating Development and Immunity

    • J. L. Imler, J. A. Hoffmann
    Pages 63-79

  6. Toll-Like Receptors and Their Ligands

    • G. M. Barton, R. Medzhitov
    Pages 81-92

  7. Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin

    • K. D. Smith, A. Ozinsky
    Pages 93-108

  8. TLR4 as the Mammalian Endotoxin Sensor

    • B. Beutler
    Pages 109-120

  9. TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns

    • C. J. Kirschning, R. R. Schumann
    Pages 121-144

  10. Bacterial CpG-DNA Licenses TLR9

    • S. Bauer, H. Wagner
    Pages 145-154

  11. MyD88 as a Bottle Neck in Toll/IL-1 Signaling

    • O. Takeuchi, S. Akira
    Pages 155-164

  12. Heat Shock Proteins as Ligands of Toll-Like Receptors

    • R. M. Vabulas, H. Wagner, H. Schild
    Pages 169-184

  13. Back Matter

    Pages 185-192
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Keywords

About this book

On occasion, the innate immune system is referred to as the "primitive" immune system. Perhaps this has dissuaded immu­ nologists from analyzing it as energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisti­ cated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due. Any immune system has two cardinal functions. It must destroy a broad range of pathogens, and it must spare the host. The adaptive immune system has applied a modular solution to these problems. Each cell of the adaptive immune system is prescreened to eliminate those that would produce untoward interactions with self; each cell is pre-programmed to recognize a foreign epitope that the host might one day encounter. Hence, the duties of each individual lymphocyte are quite circumscribed.

Editors and Affiliations

  • Department of Immunology, The Scripps Research Institute, La Jolla, USA

    Bruce Beutler

  • Institut für Medizinische Mikrobiologie, Immunologie and Hygiene Technische Universität München, München, Germany

    Hermann Wagner

Bibliographic Information

  • Book Title: Toll-Like Receptor Family Members and Their Ligands

  • Editors: Bruce Beutler, Hermann Wagner

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-59430-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2002

  • Softcover ISBN: 978-3-642-63975-3Published: 18 September 2011

  • eBook ISBN: 978-3-642-59430-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 192

  • Number of Illustrations: 6 illustrations in colour

  • Topics: Immunology

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