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The Proteasome — Ubiquitin Protein Degradation Pathway

  • Book
  • © 2002

Overview

Editors:
  1. Peter Zwickl

    1. Department of Molecular Structural Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany

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  2. Wolfgang Baumeister

    1. Department of Molecular Structural Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 268)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-ix
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  2. Molecular Evolution of Proteasomes

    • C. Volker, A. N. Lupas
    Pages 1-22

  3. The 20S Proteasome

    • P. Zwickl
    Pages 23-41

  4. Regulating the 26S Proteasome

    • M. H. Glickman, V. Maytal
    Pages 43-72

  5. The 11S Regulators of 20S Proteasome Activity

    • C. P. Hill, E. I. Masters, F. G. Whitby
    Pages 73-89

  6. Immunological Functions of the Proteasome

    • G. Niedermann
    Pages 91-136

  7. Natural Substrates of the Proteasome and Their Recognition by the Ubiquitin System

    • H. D. Ulrich
    Pages 137-174

  8. The Intracellular Localization of the Proteasome

    • C. Gordon
    Pages 175-184

  9. Proteasome Inhibitors: Complex Tools for a Complex Enzyme

    • M. Bogyo, E. W. Wang
    Pages 185-208

  10. Back Matter

    Pages 209-213
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Keywords

About this book

This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu­ lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui­ tination machinery. The penultimate chapter rounds up the in­ formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.

Editors and Affiliations

  • Department of Molecular Structural Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany

    Peter Zwickl, Wolfgang Baumeister

Bibliographic Information

  • Book Title: The Proteasome — Ubiquitin Protein Degradation Pathway

  • Editors: Peter Zwickl, Wolfgang Baumeister

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-59414-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2002

  • Softcover ISBN: 978-3-642-63971-5Published: 18 September 2011

  • eBook ISBN: 978-3-642-59414-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 208

  • Topics: Microbiology, Immunology

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