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Restoring Function to the Injured Human Spinal Cord

  • Book
  • © 2003

Overview

Authors:
  1. Richard Ben Borgens

    1. School of Veterinary Medicine, Purdue University, West Lafayette, USA
      School of Engineering, Purdue University, West Lafayette, USA

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 171)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XVI
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  2. A Brief Primer on Spinal Cord Injury

    • Richard Ben Borgens
    Pages 1-2

  3. The Behavioral Catastrophe Is Rooted in Injury to White Matter

    • Richard Ben Borgens
    Pages 3-17

  4. The Scar as a Barrier to Regeneration

    • Richard Ben Borgens
    Pages 19-24

  5. Treating the Acute and Chronic Injury: Historical Perspective

    • Richard Ben Borgens
    Pages 25-27

  6. Concerning Behavioral Models for Spinal Cord Injury in Animals

    • Richard Ben Borgens
    Pages 29-40

  7. Axonal Regeneration

    • Richard Ben Borgens
    Pages 41-50

  8. Treatment Possibilities of the New Biology

    • Richard Ben Borgens
    Pages 51-66

  9. Biologically Produced Electrical Fields: Physiology Spoken Here

    • Richard Ben Borgens
    Pages 67-79

  10. Endogenous Voltages and the Reaction of the Neuron to Injury

    • Richard Ben Borgens
    Pages 81-82

  11. The Responses of Isolated Nerve Fibers in Culture to Applied DC Voltages

    • Richard Ben Borgens
    Pages 83-90

  12. Enhancing Spinal Cord Regeneration In Situ with Applied Electric Fields

    • Richard Ben Borgens
    Pages 91-103

  13. Recovery of the CTM Reflex in Spinal-Injured Guinea Pigs After Exposure to Applied Extracellular Voltages

    • Richard Ben Borgens
    Pages 105-106

  14. From a Laboratory Tool to a Clinical Application

    • Richard Ben Borgens
    Pages 107-107

  15. Naturally Occurring Spinal Injury in the Dog as a Model for Humans

    • Richard Ben Borgens
    Pages 109-117

  16. Sealing the Breach in Cell Membranes with Hydrophilic Polymers

    • Richard Ben Borgens
    Pages 119-126

  17. Recovery of Behavioral and Physiological Function In Vivo

    • Richard Ben Borgens
    Pages 127-131

  18. PEG Application in Clinical Cases of Canine Paraplegia

    • Richard Ben Borgens
    Pages 133-136

  19. Conclusion

    • Richard Ben Borgens
    Pages 137-139

  20. Back Matter

    Pages 141-161
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Keywords

About this book

This book has two major themes: one, to provide a general un­ derstanding of the biology of spinal cord injury (SCI) in ani­ mal models and their relationship to naturally occurring inju­ ry in man, and secondly, to review novel means to induce functional recovery from spinal cord injury based on develop­ mental biophysics and physiology. These are new innovations in the treatment of SCI, born of disciplines that have not re­ ceived much attention from investigators interested in the re­ pair and regeneration of the Central Nervous System (CNS). They include development of 4-Aminopyridine for chronic SCI; oscillating electrical fields and polymer infusion for acute SCI. Biochemistry, neurotransplantation techniques, and phar­ macological approaches have long dominated this literature. Curiously though, it is these former techniques that are more practical and are rapidly moving into human clinical studies, or have already begun then. All of these clinical therapies have been developed at the Center for Paralysis Research at Purdue University, mirroring the backgrounds and interests of the electrophysiologists and biophysicists of our Research Center's faculty. Two of the three experimental therapies for SCI devel­ oped at Purdue University are now in human clinical trials, and a third will soon begin. They frame the emphasis of this text.

Authors and Affiliations

  • School of Veterinary Medicine, Purdue University, West Lafayette, USA

    Richard Ben Borgens

  • School of Engineering, Purdue University, West Lafayette, USA

    Richard Ben Borgens

Bibliographic Information

  • Book Title: Restoring Function to the Injured Human Spinal Cord

  • Authors: Richard Ben Borgens

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-642-59361-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2003

  • Softcover ISBN: 978-3-540-44367-4Published: 17 April 2003

  • eBook ISBN: 978-3-642-59361-1Published: 06 December 2012

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XVI, 161

  • Number of Illustrations: 31 b/w illustrations, 30 illustrations in colour

  • Topics: Surgical Orthopedics, Neurology, Neurosurgery

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