Estrogens and Antiestrogens I

1. Front Matter

   Pages I-XXVI

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2. History of Estrogen Research

   1. History of Estrogen Research

      • C. Lauritzen

      Pages 1-14

3. Chemistry of Estrogens and Antiestrogens

   1. Front Matter

      Pages 15-15

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   2. Steroidal Estrogens

      • G. Neef

      Pages 17-41

   3. Non-steroidal Estrogens

      • J. A. Dodge, C. D. Jones

      Pages 43-53

   4. Antiestrogens and Partial Agonists

      • E. von Angerer

      Pages 55-80

   5. Structure-Activity Relationships

      • E. von Angerer

      Pages 81-108

4. Molecular Biology of Estrogenic Action

   1. Front Matter

      Pages 109-109

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   2. Structure and Function of the Estrogen Receptor

      • A. K. Hihi, W. Wahli

      Pages 111-126

   3. Estrogen-Regulated Genes

      • A. Weisz

      Pages 127-151

   4. Regulation of Constitutive and Inducible Nitric Oxide Synthase by Estrogen

      • K. Kauser, G. M. Rubanyi

      Pages 153-170

   5. Non-Genomic Effects of Estrogens

      • V. D. Ramirez, J. Zheng

      Pages 171-200

   6. Molecular Mechanisms of Antiestrogen Action

      • L. T. Seery, J. M. W. Gee, O. L. Dewhurst, R. I. Nicholson

      Pages 201-220

5. Biosynthesis and Metabolism of Endogenous Estrogens

   1. Front Matter

      Pages 221-221

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   2. Estrogen Transforming Enzymes

      • M. J. Reed, A. Purohit

      Pages 223-242

   3. Metabolism of Endogenous Estrogens

      • T. H. Lippert, H. Seeger, A. O. Mueck

      Pages 243-271

6. Physiology and Pathophysiology of Estrogens

   1. Front Matter

      Pages 273-273

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   2. Phylogeny of Estrogen Synthesis, Extragenital Distribution of Estrogen Receptors and Their Developmental Role

      • L. Sobek, V. K. Patchev

      Pages 275-297

   3. Female Reproductive Tract

      • C. Hegele-Hartung

      Pages 299-313

   4. Estrogen and Brain Function: Implications for Aging and Dementia

      • S. E. Alves, B. S. McEwen

      Pages 315-328

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli­ cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.

• Antiöstrogen
• Estrogens
• Immune System
• Regulation
• antiestrogens
• enzymes
• metabolism
• molecular mechanisms
• pathophysiology
• physiology
• Östrogen

• Leiter Forschung und Entwicklung Jenapharm GmbH & Co. KG, Jena, Germany

  Michael Oettel

• Leiter Forschung, Fertilitätskontrolle und Hormontherapie, Berlin, Germany

  Ekkehard Schillinger

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