Retinoids

1. Front Matter

   Pages I-XXVIII

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2. Metabolism, Pharmocokinetics and Action of Retinoids

   1. Front Matter

      Pages 1-1

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   2. Physical-Chemical Properties and Action of Retinoids

      • N. Noy

      Pages 3-29

   3. Biosynthesis, Absorption, Metabolism and Transport of Retinoids

      • S. Vogel, M. V. Gamble, W. S. Blaner

      Pages 31-95

   4. Retro-Retinoids: Metabolism and Action

      • E. Vakiani, J. Buck

      Pages 97-115

   5. Retinoic Acid Synthesis and Metabolism

      • W. S. Blaner, R. Piantedosi, A. Sykes, S. Vogel

      Pages 117-149

3. Binding Proteins and Nuclear Receptors

   1. Front Matter

      Pages 151-151

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   2. Nuclear Retinoid Receptors and Mechanisms of Action

      • F. Javier Piedrafita, M. Pfahl

      Pages 153-184

   3. RAR-Selective Ligands: Receptor Subtype and Function Selectivity

      • R. L. Beard, R. A. S. Chandraratna

      Pages 185-213

   4. RXR-Specific Agonists and Modulators: A New Retinoid Pharmacology

      • I. G. Schulman, D. Crombie, R. P. Bissonnette, R. Cesario, K. Roegner, G. Shao et al.

      Pages 215-235

4. Differentiation, Proliferation, and Cancer

   1. Front Matter

      Pages 237-237

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   2. Growth Control by Retinoids: Regulation of Cell Cycle Progression and Apoptosis

      • B. Harvat, A. M. Jetten

      Pages 239-276

   3. Retinoids and Differentiation of Normal and Malignant Hematopoietic Cells

      • A. Agadir, C. Chomienne

      Pages 277-300

   4. The Retinoids: Cancer Therapy and Prevention Mechanisms

      • K. Nason-Burchenal, E. Dmitrovsky

      Pages 301-322

   5. Aberrant Expression and Function of Retinoid Receptors in Cancer

      • X.-C. Xu, R. Lotan

      Pages 323-343

5. Development and Teratogenesis

   1. Front Matter

      Pages 345-345

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   2. Genetic and Molecular Approaches to Understanding the Role of Retinoids in Mammalian Spermatogenesis

      • A. I. Packer, D. J. Wolgemuth

      Pages 347-368

   3. The Role of Retinoids in Vertebrate Limb Morphogenesis: Integration of Retinoid- and Cytokine-Mediated Signal Transduction

      • H.-C. Lu, C. Thaller, G. Eichele

      Pages 369-398

   4. Retinoids in Neural Development

      • M. Maden

      Pages 399-442

   5. Avian Embryo as Model for Retinoid Function in Early Development

      • M. H. Zile

      Pages 443-464

In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re­ cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper­ imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.

• Nuclear receptors
• Regulation
• Retinoide
• Retinoids
• Sperma
• Teratogenesis
• Vitamin A
• metabolism

• Department of Food Toxicology Center of Food Science, School of Veterinary Medicine, Hannover, Germany

  Heinz Nau

• Department of Medicine Division of Preventive Medicine & Nutrition, College of Physicians and Surgeons of Columbia University, New York, USA

  William S. Blaner

Policies and ethics