The Peroxidase Multigene Family of Enzymes

1. Front Matter

   Pages I-XII

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2. Peroxidases: A Historical Overview of Milestones in Research on Myeloperoxidase

   • Robert A. Clark

   Pages 1-10

3. Targeting of Proteins to Lysosomes and Granules

   • Andrej Hasilik

   Pages 11-21

4. Sorting and Processing of Neutrophil Granule Proteins

   • Urban Gullberg, Niklas Bengtsson, Elinor Bülow, Daniel Garwicz, Anders Lindmark, Inge Olsson

   Pages 22-30

5. X-Ray Crystallographic Studies of Human Myeloperoxidase

   • C. A. Davey, T. Fiedler, R. E. Fenna

   Pages 31-37

6. Structural and Biological Properties of Human Recombinant Myeloperoxidase

   • Nicole Moguilevsky, Alex Bollen

   Pages 38-44

7. Recent Insights into the Biosynthesis and Processing of Human Myeloperoxidase

   • William M. Nauseef

   Pages 45-51

8. Targets for Myeloperoxidase-Dependent Bactericidal Activity

   • Henry Rosen

   Pages 52-57

9. Reactions of Myeloperoxidase and Production of Hypochlorous Acid in Neutrophil Phagosomes

   • Christine C. Winterbourn, Christine J. van Dalen, Mark B. Hampton, Anthony J. Kettle

   Pages 58-67

10. Acquisition and Use of Myeloperoxidase in the Microbicidal Activity of Macrophages

    • Laszlo Marodi, Christopher Tourney, Rita Kaposzta, Richard B. Johnston Jr., Nicole Moguilevsky

    Pages 68-71

11. Cooperative Interactions of the Peroxidase and Nitric Oxide Pathways in Inflammatory Oxidant Production

    • Jason P. Eiserich, Bruce A. Freeman, Carroll E. Cross, Albert van der Vliet

    Pages 72-85

12. The Role of the Monoclonal Antibody Anti-Myeloperoxidase (anti-MPO) in the Diagnosis and Classification of Acute Leukaemias

    • Estella Matutes

    Pages 86-92

13. The Role of Myeloperoxidase in Myeloid Leukemia and Multiple Sclerosis

    • Wanda F. Reynolds

    Pages 93-101

14. Pathways for Oxidative Tissue Injury by Myeloperoxidase

    • Jay W. Heinecke

    Pages 102-106

15. Myeloperoxidase Activity of Neutrophils in Cystic Fibrosis

    • Véronique Witko-Sarsat

    Pages 107-113

16. Structure Function Relationships Amongst Members of the Animal Peroxidase Family of Proteins

    • Rosa Pia Ferrari, Silvio Traversa

    Pages 114-121

17. Myeloperoxidase (MPO) and Eosinophil Peroxidase (EPO) Deficiency in the Region Friuli-Venezia Giulia of North-Eastern Italy

    • Pierluigi Patriarca, Maurizio Romano

    Pages 122-128

18. Biochemistry and Physiology of Thyroid Peroxidase

    • Jan J. M. de Vijlder, Hennie Bikker

    Pages 129-132

19. Severe Congenital Hypothyroidism Caused by Mutations in the Thyroid Peroxidase Gene

    • Hennie Bikker, Jan J. M. de Vijlder

    Pages 133-135

20. Screening for Leukocyte Peroxidase Deficiencies by Means of Flow Cytometry: Application to the Study of Prevalence, Pathology and Genetics

    • Dolphe Kutter, Luc Verstraeten

    Pages 136-144

In September 1998 experts from 19 countries came together for an interdisciplinary discussion of the function of animal peroxidases, a family of enzymes embracing myeloperoxidase, eosinophil peroxidase, thyroid peroxidase and lactoperoxidase. Their papers have been updated for publication, yielding a wide-ranging overview of the state of the art. The chapters cover a wide range of topics, including three-dimensional structure of representative family members, their biosynthesis and intracellular transport, mechanism of action as well as applications to clinical medicine. They are of clinical relevance in, for example, arteriosclerosis, multiple sclerosis, infections, tumorigenesis, rheumatic diseases and hypothyroidism. This book forms an excellent introduction for anyone interested in the peroxidase family of enzymes.

• arteriosklerosis
• cancer
• classification
• hyothyroidism
• peroxidase
• rheumatic diseases
• tumorigenesis

• Department of Medicine, Charité Humboldt University of Berlin, Berlin, Germany

  Petro E. Petrides

• Inflammation Program and Departments of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, USA

  William M. Nauseef

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