Lymphatic Metastasis and Sentinel Lymphonodectomy

1. Front Matter

   Pages I-XII

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2. Clinical Assessment of Lymph Node Metastases

   1. Front Matter

      Pages 1-1

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   2. Efficacy of Immunoscintigraphy for Detection of Lymph Node Metastases

      • K. E. Britton, H. Jan, A. R. Al-Yasi, L. Biassoni, M. J. Carroll, M. Granowska

      Pages 3-11

   3. Sensitivity and Specificity of Positron Emission Tomography (PET) for the Diagnosis of Lymph Node Metastases

      • L. G. Strauss

      Pages 12-19

   4. Diagnosis and Staging of Lymph Node Metastasis

      • Ch. Wittekind

      Pages 20-28

   5. Detection and Relevance of Immunohistochemically Identifiable Tumor Cells in Lymph Nodes

      • B. Passlick, K. Pantel

      Pages 29-37

3. Principles of Lymphatic Metastasis

   1. Front Matter

      Pages 39-39

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   2. Cell Biology of Lymphatic Metastasis The Potential Role of c-erbB Oncogene Signalling

      • S. A. Eccles

      Pages 41-54

   3. The Lymph Node as a Bridgehead in the Metastatic Dissemination of Tumors

      • J. P. Sleeman

      Pages 55-81

   4. Functional Anatomy of Lymphatic Vessels Under the Aspect of Tumor Invasion

      • A.-A. Duenne, J. A. Werner

      Pages 82-89

   5. Molecular Diagnosis of Head and Neck Cancer

      • V. M. M. van Houten, M. W. M. van den Brekel, F. Denkers, D. R. Colnot, J. Westerga, P. J. van Diest et al.

      Pages 90-106

4. Principles of Lymphatic Mapping and Sentinel Node Detection

   1. Front Matter

      Pages 107-107

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   2. The Concept of the Sentinel Lymph Node

      • R. M. Cabanas

      Pages 109-120

   3. Sentinel Node Localization by Lymphoscintigraphy: A Reliable Technique with Widespread Applications

      • G. Paganelli, C. De Cicco, M. Chinol

      Pages 121-129

   4. Vital Dye and Radiolabelled Colloids — Complement or Alternative

      • R. Pijpers, P. J. Borgstein, G. J. J. Teule, S. Meijer

      Pages 130-137

5. Sentinel Node Detection in Urogenital Cancer

   1. Front Matter

      Pages 139-139

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   2. Application of the Sentinel Node Concept in Urogenital Cancer

      • R. M. Cabanas

      Pages 141-149

   3. Intraoperative Lymphatic Mapping and Sentinel Node Identification: Gynecologic Applications

      • C. Levenback

      Pages 150-158

6. Sentinel Node Detection in Malignant Melanoma

   1. Front Matter

      Pages 159-159

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   2. Sentinel Node Detection in Malignant Melanoma

      • A. D. Chan, D. L. Morton

      Pages 161-177

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl­ edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re­ cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in­ creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im­ prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu­ mor biological viewpoints. World-renowned experts with long­ term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.

• Lymph node metastasis
• Staging
• Tumor
• biopsy
• carcinoma
• cell biology
• diagnosis
• fluorescence
• lymphating mapping
• lymphonodectomy
• positron emission tomography
• sentinel lymph node
• surgery
• tumor staging
• ultrasound

• Klinik für Chirurgie und chirurgische Onkologie Robert-Rössle-Klinik, Universitätsklinikum Charité, Berlin, Germany

  Peter M. Schlag

• Istituto Europeo di Oncologia, Milano, Italy

  Umberto Veronesi

Policies and ethics