Pharmacology of Ionic Channel Function: Activators and Inhibitors

1. Front Matter

   Pages I-XXXI

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2. Voltage-Dependent Ion Channels A. Voltage-Dependent na Channels

   1. Front Matter

      Pages 1-1

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   2. Structure and Functions of Voltage-Dependent Na+ Channels

      • K Imoto

      Pages 3-26

   3. Sodium Channel Blockers and Activators

      • A. O. Grant

      Pages 27-51

   4. Classification and Function of Voltage-Gated Calcium Channels

      • J. B. Bergsman, D. B. Wheeler, R. W. Tsien

      Pages 55-85

   5. Structure of the Voltage-Dependent L-Type Calcium Channel

      • F. Hofmann, N. Klugbauer

      Pages 87-117

   6. Ca2+Channel Antagonists and Agonists

      • S Adachi-Akahane, T. Nagao

      Pages 119-154

   7. Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity

      • Y. Kubo

      Pages 157-176

   8. Pharmacology of Voltage-Gated Potassium Channels

      • O. Pongs, C. Legros

      Pages 177-196

   9. Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology

      • R. Latorre, C. Vergara, O. Alvarez, E. Stefani, L. Toro

      Pages 197-223

   10. Classical Inward Rectifying Potassium Channels: Mechanisms of Inward Rectification

       • C. G. Nichols

       Pages 225-242

   11. ATP-Dependent Potassium Channels in the Kidney

       • G. Giebisch, W. Wang, S. C. Hebert

       Pages 243-270

   12. Structure and Function of ATP-Sensitive K+ Channels

       • T. Gonoi, S. Seino

       Pages 271-295

   13. G Protein-Gated K+ Channels

       • A. Inanobe, Y. Kurachi

       Pages 297-331

   14. Potassium Channels with Two Pore Domains

       • F. Lesage, M. Lazdunski

       Pages 333-345

   15. Cardiac K+ Channels and Inherited Long QT Syndrome

       • M.-D. Drici, J. Barhanin

       Pages 347-362

3. Ligand Operated Ion Channels

   1. Front Matter

      Pages 363-363

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   2. Gating of Ion Channels by Transmitters: The Range of Structures of the Transmitter-Gated Channels

      • A. E. Barnard

      Pages 365-392

   3. Molecular Diversity, Structure, and Function of Glutamate Receptor Channels

      • M. Mishina

      Pages 393-414

   4. Glutamate Receptor Ion Channels: Activators and Inhibitors

      • D. E. Jane, H. W. Tse, D. A. Skifter, J. M. Christie, D. T. Monaghan

      Pages 415-478

Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.

• ATP
• Calcium
• Glutamat
• Ion channel
• Ionenkanal
• Nucleotide
• Regulation
• Zellmembran
• cell membrane
• classification

• Saitama Medical School, Saitama, Japan

  Makato Endo

• Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, Osaka, Japan

  Yoshihisa Kurachi

• Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Tokyo, Japan

  Masayoshi Mishina

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