Skip to main content
SpringerLink
Log in

Endothelin and Its Inhibitors

  • Book
  • © 2001

Overview

Editors:
  1. Timothy D. Warner

    1. Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute St. Barthomew’s and the Royal London School of Medicine and Dentistry, London, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Since its characterisation in 1988, endothelin research has moved very rapidly.
  • A little over 10 years of research have produced the most dramatic developments.
  • Recent publications have addressed specific aspects of endothelins.
  • In this book, however, are collected reviews that cover, systematically, every area of our knowledge regarding the endothelins

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 152)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages I-XXIV
    Download chapter PDF

  2. Historical Perspective and Introduction to the Endothelin Family of Peptides

    • T. Masaki
    Pages 1-9

  3. Sarafotoxins and Their Relationship to the Endothelin Family of Peptides

    • M. Sokolovsky, Z. Shraga-Levine
    Pages 11-34

  4. Identity of Endothelin-Converting Enzyme and Other Targets for the Therapeutic Regulation of Endothelin Biosynthesis

    • R. Corder
    Pages 35-67

  5. Endothelin Receptors

    • P. J. Henry, R. G. Goldie
    Pages 69-114

  6. Cell Signaling by Endothelin Peptides

    • M. S. Simonson
    Pages 115-140

  7. Lessons from Gene Deletion of Endothelin Systems

    • H. Kurihara, Y. Kurihara, Y. Yazaki
    Pages 141-154

  8. Endothelin-Converting Enzyme Inhibitors and their Effects

    • B. Battistini, A. Y. Jeng
    Pages 155-208

  9. Endothelin Converting Enzymes and Endothelin Receptor Localisation in Human Tissues

    • A. P. Davenport, F. D. Russell
    Pages 209-237

  10. Endothelin Receptor Antagonists

    • J. D. Elliott, J.-N. Xiang
    Pages 239-270

  11. Toxicology of Endothelin Antagonists

    • S. J. Morgan, P. K. Cusick, B. A. Trela
    Pages 271-275

  12. Endothelins and the Release of Autacoids

    • P. D’OrlĂ©ans-Juste, G. Bkaily, M. Duval, J. LabontĂ©, M. Plante, G. Cournoyer et al.
    Pages 277-298

  13. The Roles of Endothelins in Proliferation, Apoptosis, and Angiogenesis

    • J. R. Wu-Wong, T. J. Opgenorth
    Pages 299-322

  14. The Involvement of Endothelins in Cerebral Vasospasm and Stroke

    • O. Touzani, J. McCulloch
    Pages 323-356

  15. Involvement of the Endothelins in Airway Reactivity and Disease

    • R. G. Goldie, P. J. Henry
    Pages 357-387

  16. Endothelin-1 and Pulmonary Hypertension

    • D. J. Stewart, Y. D. Zhao
    Pages 389-404

  17. Vascular and Cardiac Effects of Endothelin

    • S. A. Douglas, E. H. Ohlstein
    Pages 405-451

  18. Endothelins Within the Liver and the Gastrointestinal System

    • B. Battistini
    Pages 453-475

  19. Endothelin and the Kidney

    • D. M. Pollock
    Pages 477-501

  20. Endothelin Ligands and their Experimental Effects Within the Human Circulation

    • S. J. Leslie, D. J. Webb
    Pages 503-520
Back to top

Keywords

About this book

Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.

Editors and Affiliations

  • Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute St. Barthomew’s and the Royal London School of Medicine and Dentistry, London, UK

    Timothy D. Warner

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation