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Nuclear Export of Viral RNAs

  • Book
  • © 2001

Overview

Editors:
  1. Joachim Hauber

    1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Erlangen, Germany

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  2. Peter K. Vogt

    1. Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 259)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-IX
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  2. Nuclear Export of Herpes Virus RNA

    • R. M. Sandri-Goldin
    Pages 1-23

  3. Nuclear Export of Adenovirus RNA

    • T. Dobner, J. Kzhyshkowska
    Pages 25-54

  4. Nuclear Export Mediated by the Rev/Rex Class of Retroviral Trans-activator Proteins

    • J. Hauber
    Pages 55-76

  5. Constitutive Transport Element-Mediated Nuclear Export

    • M.-L. Hammarskjöld
    Pages 77-93

  6. Nuclear Pore Complex Architecture and Functional Dynamics

    • B. Fahrenkrog, D. Stoffler, U. Aebi
    Pages 95-117

  7. Methods and Assays to Investigate Nuclear Export

    • R. H. Stauber
    Pages 119-128

  8. Back Matter

    Pages 129-134
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Keywords

About this book

In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro­ molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro­ vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detailed dissection of the function of the human immunodeficiency virus type I (HIV-I) Rev trans-activator protein identified CRMI, as a hona fide nuclear export receptor. CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that have subsequently been found to contain a Rev-type leucine-rich nuclear export signal (NES).

Editors and Affiliations

  • Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Erlangen, Germany

    Joachim Hauber

  • Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Nuclear Export of Viral RNAs

  • Editors: Joachim Hauber, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-56597-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2001

  • Hardcover ISBN: 978-3-540-41278-6Published: 27 March 2001

  • Softcover ISBN: 978-3-642-62522-0Published: 21 October 2012

  • eBook ISBN: 978-3-642-56597-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 134

  • Topics: Microbiology, Virology

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