Protein Degradation in Health and Disease

1. Front Matter

   Pages I-X

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2. Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth

   • Takumi Kamura, Joan W. Conaway, Ronald C. Conaway

   Pages 1-15

3. Aging of Proteins and the Proteasome

   • Bertrand Friguet

   Pages 17-33

4. Protein Degradation in the Aging Organism

   • Walter F. Ward

   Pages 35-42

5. Protein Degradation in Alzheimer’s Disease and Aging of the Brain

   • Teruyuki Tsuji, Shun Shimohama

   Pages 43-60

6. Protein Degradation in Human Disease

   • Richard K. Plemper, Anthea L. Hammond

   Pages 61-84

7. The 26S Proteasome

   • Olivier Coux

   Pages 85-107

8. Proteasome Inhibitors

   • Michèle Reboud-Ravaux

   Pages 109-125

9. Back Matter

   Pages 127-130

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Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

• Krebs
• Proteinabbau
• aging
• alzheimer's disease
• cancer
• cell
• central nervous system
• development
• diseases
• metabolism
• pathology
• proliferation
• protein
• proteins
• regulation

• Laboratoire d’Enzymologie Moléculaire et Fonctionnelle Département de Biologie Cellulaire Institut Jacques Monod, Universités Paris VI & VII, Paris Cedex 05, France

  Michèle Reboud-Ravaux

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