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Molecular Genetic Epidemiology

A Laboratory Perspective

  • Book
  • © 2002

Overview

Editors:
  1. Ian N. M. Day

    1. Human Genetics Research Division Duthie Building (MP 808), Southampton General Hospital, Southampton, UK

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  • Principles and practice of molecular techniques used in Epidemiology
  • Special emphasis on high-throughput technologies
  • Includes supplementary material: sn.pub/extras

Part of the book series: Principles and Practice (PRINCIPLES)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XII
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  2. Mapping Genes for Common Diseases: Statistical Planning, Power, Efficiency and Informatics

    • Andy Collins
    Pages 1-26

  3. Human DNA Sampling and Banking

    • Emmanuel Spanakis
    Pages 27-53

  4. Microsatellite Genotyping

    • Cheni Kwok, Karin Schmitt
    Pages 55-85

  5. Minisatellite and Microsatellite DNA Fingerprinting

    • Paul G. Debenham
    Pages 87-106

  6. Multiplex Polymerase Chain Reaction and Immobilized Probes: Application to Cardiovascular Disease

    • Suzanne Cheng
    Pages 107-129

  7. The Special Case of HLA Genes: Detection and Resolution of Multiple Polymorphic Sites in a Single Gene

    • W. Martin Howell, Katherine L. Poole
    Pages 131-156

  8. Microplate Array Diagonal Gel Electrophoresis (MADGE) Methodologies: The First Five Years

    • Ian N. M. Day, Emmanuel Spanakis, Lesley J. Hinks, Anca Voropanov, Xaio-He Chen, Sandra D. O’dell
    Pages 157-181

  9. The Use of Sequence Analysis for Homozygote and Heterozygote Base Variation Discovery

    • Hans-Ulrich Thomann, Michael FitzGerald, Heidi Giese, Kristen Wall
    Pages 183-210

  10. Back Matter

    Pages 211-214
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Keywords

About this book

This volume describes high-throughput approaches to a series of robust, established methodologies in molecular genetic studies of population samples. Such developments have been essential not only to linkage and association studies of single-gene and complex traits in humans, animals and plants, but also to the characterisation of clone banks, for example in mapping of genomes. Chapters have been written by developers or highly experienced end-users concerned with a diverse array of biological applications. The book should appeal to any researcher for whom costs and throughput in their genetics laboratory have become an issue.

Editors and Affiliations

  • Human Genetics Research Division Duthie Building (MP 808), Southampton General Hospital, Southampton, UK

    Ian N. M. Day

Bibliographic Information

  • Book Title: Molecular Genetic Epidemiology

  • Book Subtitle: A Laboratory Perspective

  • Editors: Ian N. M. Day

  • Series Title: Principles and Practice

  • DOI: https://doi.org/10.1007/978-3-642-56207-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2002

  • Hardcover ISBN: 978-3-540-41388-2Published: 23 October 2001

  • Softcover ISBN: 978-3-540-41387-5Published: 23 October 2001

  • eBook ISBN: 978-3-642-56207-5Published: 01 December 2013

  • Series ISSN: 1866-914X

  • Series E-ISSN: 1866-9158

  • Edition Number: 1

  • Number of Pages: XII, 214

  • Number of Illustrations: 204 b/w illustrations, 1 illustrations in colour

  • Topics: Cell Biology, Biochemistry, general, Human Genetics, Molecular Medicine, Cancer Research

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