Skip to main content
SpringerLink
Log in
Book cover

Protein Complexes that Modify Chromatin

  • Book
  • © 2003

Overview

Editors:
  1. J. L. Workman

    1. Howard Hughes Medical Institute Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 274)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (10 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Nucleosome Assembly and Remodeling

    • T. Ito
    Pages 1-22

  3. Chromatin Proteins Are Determinants of Centromere Function

    • J. A. Sharp, P. D. Kaufman
    Pages 23-52

  4. HP1 Complexes and Heterochromatin Assembly

    • R. Kellum
    Pages 53-77

  5. SMC Protein Complexes and the Maintenance of Chromosome Integrity

    • K. Yokomori
    Pages 79-112

  6. Selective Gene Regulation by SWI/SNF-Related Chromatin Remodeling Factors

    • K. R. Katsani, T. Mahmoudi, C. P. Verrijzer
    Pages 113-141

  7. The SWI/SNF Family of ATP-Dependent Chromatin Remodelers: Similar Mechanisms for Diverse Functions

    • W. Wang
    Pages 143-169

  8. Changing the DNA Landscape: Putting a SPN on Chromatin

    • T. Formosa
    Pages 171-201

  9. The MYST Family of Histone Acetyltransferases

    • R. T. Utley, J. Côté
    Pages 203-236

  10. N-CoR-HDAC Corepressor Complexes: Roles in Transcriptional Regulation by Nuclear Hormone Receptors

    • P. L. Jones, Y.-B. Shi
    Pages 237-268

  11. The NuRD Complex: Linking Histone Modification to Nucleosome Remodeling

    • Q. Feng, Y. Zhang
    Pages 269-290

  12. Back Matter

    Pages 291-298
    Download chapter PDF
Back to top

Keywords

About this book

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten­ sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans­ acting factors. Our view of eukaryotic chromosomes has evolved dra­ matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi­ lize nucleosomes or stabilize nucleosomes. Awide variety of such com­ plexes have now been described. Some are abundant and may play glo­ bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

Reviews

From the reviews:

"This volume of Current Topics in Microbiology and Immunology entitled ‘Protein Complexes that Modify Chromatin’ takes the reader on a detailed voyage through chromatin. … The book is divided into ten chapters, each contributed by experts in the field of chromatin. … presents a detailed overview of the protein complexes that associates with chromatin. … is a great reference for researchers who are specifically interested in chromatin and its associated proteins."(Yassmine Akkari, The Journal of the Association of Genetic Technologists, Vol. 30 (1), 2004)

"This book provides timely reviews of several protein complexes that regulate gene expression and chromatin dynamics. Examples of such complexes include nucleosome assembly complexes, ATP-dependent chromatin remodeling complexes … . These chapters will bring experts in the field up to date on several aspects of chromosome biology and will provide an exciting introduction to the field for new chromatin researchers." (Journal of Investigational Allergology & Clinical Immunology, Vol. 13 (3), 2003)

Editors and Affiliations

  • Howard Hughes Medical Institute Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, USA

    J. L. Workman

Bibliographic Information

  • Book Title: Protein Complexes that Modify Chromatin

  • Editors: J. L. Workman

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-55747-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2003

  • Hardcover ISBN: 978-3-540-44208-0Published: 08 January 2003

  • Softcover ISBN: 978-3-642-62909-9Published: 23 October 2012

  • eBook ISBN: 978-3-642-55747-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 298

  • Topics: Human Genetics

Publish with us

Policies and ethics

Back to top

Search

Navigation