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The Macrophage as Therapeutic Target

  • Book
  • © 2003

Overview

Editors:
  1. Siamon Gordon

    1. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 158)

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Table of contents (23 chapters)

  1. Front Matter

    Pages I-X
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  2. General

    1. Front Matter

      Pages 1-1
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    2. The Macrophage as a Validated Pharmaceutical Target

      • H. Rosen
      Pages 3-10

    3. Transcription Factors That Regulate Macrophage Development and Function

      • D. A. Hume, S. R. Himes
      Pages 11-40

    4. Exploitation of Macrophage Clearance Functions In Vivo

      • S. M. Moghimi
      Pages 41-54

    5. Reaching the Macrophage: Routes of Delivery

      • G. Kraal, N. van Rooijen
      Pages 55-65

    6. Antigen-Presenting Cells and Vaccine Design

      • S. Y. C. Wong, L. Martinez-Pomares
      Pages 67-87

    7. Macrophage-Specific Gene Targeting In Vivo

      • D. R. Greaves, S. Gordon
      Pages 89-107

  3. Macrophage Targets in Inflammation

    1. Front Matter

      Pages 109-109
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    2. Integrins of Macrophages and Macrophage-Like Cells

      • E. J. Brown
      Pages 111-130

    3. Macrophage Targets in Inflammation: Purinergic Receptors

      • F. Di Virgilio, D. Ferrari
      Pages 131-146

    4. Macrophage Lipid Uptake and Foam Cell Formation

      • W. J. S. de Villiers, D. R. van der Westhuyzen
      Pages 147-172

    5. Dietary Fatty Acids and Macrophages

      • P. C. Calder, P. Yaqoob
      Pages 173-192

    6. Macrophages as Therapeutic Targets in Lysosomal Storage Disorders

      • J. M. Aerts, C. Hollak, R. Boot, A. Groener
      Pages 193-208

    7. Nuclear Receptors as Regulators of Macrophage Homeostasis and Function

      • J. S. Welch, C. K. Glass
      Pages 209-225

    8. Relationships Between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages

      • M. G. Espey
      Pages 227-252

    9. Proteases

      • J. A. Mahoney
      Pages 253-268

    10. Targeting the Chemokine System

      • Z. Johnson, A. Frauenschuh, A. E. I. Proudfoot
      Pages 269-294

    11. Antimicrobial Peptides

      • T. Ganz, R. I. Lehrer
      Pages 295-304

    12. Macrophage Phospholipid Products

      • P. M. Henson
      Pages 305-334
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Keywords

About this book

During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents.

The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.

Editors and Affiliations

  • Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    Siamon Gordon

Bibliographic Information

  • Book Title: The Macrophage as Therapeutic Target

  • Editors: Siamon Gordon

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-55742-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2003

  • Hardcover ISBN: 978-3-540-44250-9Published: 10 July 2003

  • Softcover ISBN: 978-3-642-62919-8Published: 23 October 2012

  • eBook ISBN: 978-3-642-55742-2Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: X, 496

  • Topics: Immunology, Pharmacology/Toxicology, Virology

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