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Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management

  • Book
  • © 2014

Overview

Editors:
  1. Jacob P. Thyssen

    1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  2. Howard I. Maibach

    1. Department of Dermatology, University of California, San Francisco, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First book to be devoted to the subject

  • Comprehensive overview of the effects of FLG mutations in health and disease

  • Wide appeal to the many different specialties that work with this area

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Table of contents (36 chapters)

  1. Front Matter

    Pages i-xv
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  2. Basic Science

    1. Front Matter

      Pages 1-1
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    2. Function of Filaggrin and Its Metabolites

      • Sanja Kezic
      Pages 3-8

    3. Morphology of Filaggrin-Depleted Epidermis

      • Robert Gruber
      Pages 9-21

    4. Stratum Corneum Lipids and Filaggrin

      • Jakob Mutanu Jungersted
      Pages 23-26

    5. Inflammatory-Driven Depletion of Filaggrin Proteins

      • Christian Vestergaard, Mette S. Deleuran
      Pages 27-36

    6. Immune Activity and Vitamin D

      • Charlotte M. Bonefeld, Morten M. Nielsen, Carsten Geisler
      Pages 37-47

    7. Filaggrin-2

      • Jens-Michael Schröder, Britta Hansmann
      Pages 49-62

  3. Identification and Study Methods

    1. Front Matter

      Pages 63-63
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    2. Animal Models

      • Kozo Nakai, Kozo Yoneda, Yasuo Kubota
      Pages 65-74

    3. In Vitro Models of Filaggrin-Associated Diseases

      • Sarah Küchler
      Pages 75-81

    4. Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics

      • David L. Stenoien
      Pages 83-92

    5. Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy

      • Francisco J. González
      Pages 93-101

    6. Filaggrin Genotyping

      • Pal B. Szecsi, Michael Meldgaard
      Pages 103-116

  4. Epidemiology and Environmental Exposures

    1. Front Matter

      Pages 117-117
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    2. Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective

      • Marten C. G. Winge, Maria Bradley
      Pages 119-128

    3. Filaggrin Gene Mutations in Asian Races

      • Ruhong Cheng, Ming Li, Hui Zhang, Zhirong Yao
      Pages 129-135

    4. Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals

      • Ulla N. Joensen, Jacob P. Thyssen
      Pages 137-140

  5. Filaggrin and Atopic Disease

    1. Front Matter

      Pages 141-141
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    2. Filaggrin Mutations and the Atopic March

      • Jennifer R. Heimall, Jonathan M. Spergel
      Pages 143-151
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Keywords

About this book

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

Editors and Affiliations

  • Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  • Department of Dermatology, University of California, San Francisco, USA

    Howard I. Maibach

About the editors

Jacob Thyssen has worked in Dermatology for 10 years and holds PhD and DmSci degrees from the University of Copenhagen. He has published 190 articles and 10 book chapters. He has received international awards for his research, including the LEO Pharma Research Foundation for best investigator <45 years in the Nordic countries. His research has focused on dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. He is a regular speaker at international meetings. Jacob Thyssen enjoys treating patients with dermatitis on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.

Bibliographic Information

  • Book Title: Filaggrin

  • Book Subtitle: Basic Science, Epidemiology, Clinical Aspects and Management

  • Editors: Jacob P. Thyssen, Howard I. Maibach

  • DOI: https://doi.org/10.1007/978-3-642-54379-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-642-54378-4Published: 24 June 2014

  • Softcover ISBN: 978-3-662-51117-6Published: 23 August 2016

  • eBook ISBN: 978-3-642-54379-1Published: 27 May 2014

  • Edition Number: 1

  • Number of Pages: XV, 373

  • Number of Illustrations: 78 b/w illustrations, 82 illustrations in colour

  • Topics: Dermatology, Allergology, Pneumology/Respiratory System, Ophthalmology

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