Genetics of Immunological Diseases

1. Front Matter

   Pages I-XI

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2. Localizing and Cloning Genes

   1. Front Matter

      Pages 1-1

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   2. The Long-Range Mapping of Mammalian Chromosomes

      • S. D. M. Brown, N. Brockdorff, J. S. Cavanna, E. M. C. Fisher, A. J. Greenfield, M. F. Lyon et al.

      Pages 3-12

   3. The Use of Interspecific Mouse Crosses for Gene Localization: Present Status and Future Perspectives

      • J. L. Guénet, D. Simon-Chazottes, P. R. Avner

      Pages 13-17

   4. X-Chromosome Gene Order in Different Mus Species Crosses

      • D. A. Stephenson, S. G. Grant, L. J. Mullins, A. E. Scolese, A. J. O’Reilly, V. M. Chapman

      Pages 18-24

   5. Bayesian Multilocus Linkage Mapping

      • R. D. Blank, G. R. Campbell, M. Pollak, P. D’Eustachio

      Pages 25-32

   6. The Rat Gene Map

      • C. Szpirer, J. Szpirer, M. Q. Islam, G. Levan

      Pages 33-38

   7. Linkage and Synteny Homologies in Mouse and Man

      • J. H. Nadeau, A. H. Reiner

      Pages 39-40

   8. Molecular Analysis of the Aniridia — Wilms’ Tumor Syndrome

      • N. D. Hastie, D. J. Porteous, W. Bickmore, J. Maule, V. van Heyningen

      Pages 41-46

   9. Approaching the Mouse Steel Locus from Closely Linked Molecular Markers

      • L. Stubbs, A. Poustka, D. Rohme, L. B. Russell, H. Lehrach

      Pages 47-52

3. Complex Loci Involved in the Regulation of Developmental and Immunological Processes

   1. Front Matter

      Pages 53-53

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   2. The Mouse t Complex

      1. Probing Mouse Origins with Random DNA Probes

         • J. Klein, V. Vincek, M. Kasahara, F. Figueroa

         Pages 55-63

      2. Mouse t Haplotypes: A Tale of Tails and a Misunderstood Selfish Chromosome

         • L. M. Silver

         Pages 64-69

      3. Contrasting Patterns of Evolution in the Proximal and Distal Regions of the Mouse <i>t</i> Complex

         • M. A. Erhart, S. J. Phillips, J. H. Nadeau

         Pages 70-76

      4. From Phenotype to Gene: Molecular Cloning in the <i>Brachyury (T)</i> Locus Region

         • B. G. Herrmann, H. Lehrach

         Pages 77-81

   3. Mouse Homeo Box Genes

      1. Murine Hox Genes — A Multigene Family

         • M. Fibi, M. Kessel, P. Gruss

         Pages 82-86

      2. Expression of the Homeobox Genes Hox 2.1 and 2.6 During Mouse Development

         • A. Graham, P. W. H. Holland, A. Lumsden, R. Krumlauf, B. L. M. Hogan

         Pages 87-93

   4. Immunoglobulin Superfamily Genes

      1. Studies of V(D)J Recombination with Extrachromosomal Substrates

         • M. R. Lieber, J. E. Hesse, K. Mizuuchi, M. Gellert

         Pages 94-99

      2. Transcription Factors in Terminally Differentiated B Cells

         • C. L. Peterson, B. Tsao, E. Kakkis, K. L. Calame

         Pages 100-106

      3. Selective and Neutral Evolution in the Murine <i>Igh-V</i> Locus

         • A. Tutter, R. Riblet

         Pages 107-115

The development of innovative molecular techniques such as pulse-field gel electro­ phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva­ tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

• diseases
• genetics
• immune response
• infectious disease

• Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA

  Beverly Mock, Michael Potter

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