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Platinum Coordination Complexes in Cancer Chemotherapy

  • Book
  • © 1974

Overview

Editors:
  1. T. A. Connors

    1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, UK

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  2. J. J. Roberts

    1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 48)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XII
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  3. Interaction with Biomacromolecules

    1. The Interactions of Platinum Compounds with Biological Molecules

      • A. J. Thomson
      Pages 38-62

    2. Interactions with Biomacromolecules

      • A. B. Robins
      Pages 63-78

  4. Bacterial, Viral and Tissue Culture Studies

    1. Bacterial, Viral and Tissue Culture Studies on Neutral Platinum Complexes

      • J. J. Roberts
      Pages 79-97

    2. Effects of Platinum Compounds on Bacteria, Viruses and Cells in Culture

      • H. C. Harder
      Pages 98-112

  5. Animals Studies

    1. Anti-Tumour Effects of Platinum Complexes in Experimental Animals

      • T. A. Connors
      Pages 113-123

    2. Pharmacokinetics of Platinum Compounds

      • P. B. Conran
      Pages 124-136

  6. Clinical Trials

    1. The Development and Clinical Testing of New Anticancer Drugs at the National Cancer Institute — Example cis-Platinum (II) Diamminedichloride (NSC 119 875)

      • S. K. Carter, M. Goldsmith
      Pages 137-144

    2. Further Clinical Experience with cis-Platinum (II) Diamminedichloride

      • J. M. Hill, E. Loeb, A. S. MacLellan, N. O. Hill, A. Khan, J. Kogler
      Pages 145-152

    3. Preliminary Report on Phase 1 Clinical Experience with Combined cis-diamminedichloride Platinum (II) (PDD) and 5-FU

      • R. A. Ellerby, F. J. Ansfield, H. L. Davis
      Pages 153-159

    4. Clinical Evalutions of Toxic Effects of cis-Platinum (II) Diamminedichloride

      • R. W. Talley, R. M. O’bryan, J. Gutterman, R. W. Brownlee, K. B. McCredie
      Pages 160-166

    5. Phase I Evaluation of cis-Platinum (II) Diamminedichloride (PDD) and a Combination of PDD Plus Adriamycin

      • H. J. Wallace Jr, D. J. Higby
      Pages 167-177

    6. cis-Platinum (II) Diamminedichloride

      • E. Wiltshaw, B. Carr
      Pages 178-182

    7. Clinical Trials of cis-Platinum (II) Diamminedichloride (PDD) in Patients with Advanced Cancer

      • I. H. Krakoff, A. J. Lippman
      Pages 183-190

    8. Preliminary Experience with cis-Platinum (II) Diamminedichloride (PDD)

      • Z. Dienstbier, O. Andrysek, J. Zamecnik
      Pages 191-193

    9. Clinical Experience with cis-Platinum (II) Diamminedichloride

      • I. Hindy, C. Sellei, R. Varsanyi, S. Eckhardt
      Pages 194-195

  7. Back Matter

    Pages 197-202
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Keywords

About this book

It was a great pleasure and honour to have been invited to attend this Seminar and to present a final impression. The association in this field between the Chester Beatty Research Institute and Dr. Rosenberg's School at East Lansing is something which I specially value and many would doubtless like to know how it came about. In the course of its work in carcinogenesis and on chemotherapy over many years, the Chester Beatty Research Institute was frequently drawn to the importance of many metals - as for example lead, iron, metalloid arsenic and the metalloid quali­ ties of the carcinogenic hydrocarbons. Interest started in platinum many years ago, following the possibility, c1aimed by others, that various complexes between the metal and mercaptopurine might possess significant chemotherapeutic properties. Va­ rious attempts to confirm such findings ended, however, in complete failure. Interest in platinum was revived by the fresh observations of Dr. Rosenberg and his collea­ gues, and here the outcome was entirely different. Very soon it was possible to con­ firm the intense growth-inhibitory properties of cis-platinum (II) diamminedi­ chloride and related substances. After communicating these results to Dr. Rosenberg, it was a pleasure to welcome hirn in London where he gave a Seminar which greatly engaged the interest of many of the staff. Later, several of these were to enjoy Dr. Rosenberg's hospitality at an international conference on the subject to be held in East Lansing, where many rapidly developing aspects were open for discussion.

Editors and Affiliations

  • Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, UK

    T. A. Connors, J. J. Roberts

Bibliographic Information

  • Book Title: Platinum Coordination Complexes in Cancer Chemotherapy

  • Editors: T. A. Connors, J. J. Roberts

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-49306-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1974

  • Softcover ISBN: 978-3-642-49308-9Published: 01 July 2012

  • eBook ISBN: 978-3-642-49306-5Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XII, 202

  • Number of Illustrations: 32 b/w illustrations

  • Topics: Rehabilitation, Cancer Research

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