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Investigation and Stimulation of Immunity in Cancer Patients

  • Conference proceedings
  • © 1974

Overview

Editors:
  1. Georges Mathé

    1. Institut de Cancérologie et d’Immunogénétique, Villejuif, France

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    You can also search for this editor in PubMed   Google Scholar

  2. Roy Weiner

    1. Children’s Cancer Research Foundation, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 47)

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Table of contents (74 papers)

  1. Front Matter

    Pages I-IX
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  2. Introduction

    1. Introduction

      • G. Mathé
      Pages 1-2

  3. Investigation of Immunity in Cancer Patients

    1. Front Matter

      Pages 3-3
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    2. Non Specific

      1. Selective Activation of T Lymphocytes. Its Possible Application in the Immunomanipulation of Tumours
        • J. F. A. P. Miller
        Pages 5-11
      2. Immunological Reactivity of Human Recipients of Syngeneic and Allogeneic Marrow Grafts
        • E. D. Thomas, L. Fass, H. D. Ochs, E. M. Mickelson, R. Storb, A. Fefer
        Pages 12-16
      3. Immunological Studies in Acute Leukemia
        • G. W. Santos, G. M. Mullins, W. B. Bias, P. N. Anderson, K. D. Graziano, D. L. Klein et al.
        Pages 17-24
      4. Primary and Secondary Immune Responses in the Evaluation of Immunocompetence and Prognosis in Cancer Patients
        • E. M. Hersh, E. J. Freireich, K. B. McCredie, J. U. Gutterman, G. P. Bodey Sr., J. P. Whitecar et al.
        Pages 25-36
      5. Delayed-Hypersensitivity Reactions in Patients with Cancer
        • C. M. Pinsky, A. El Domeiri, A. S. Caron, W. H. Knapper, H. F. Oettgen
        Pages 37-41
      6. Nonspecific Immune Responses in Hematosarcomas and Acute Leukemias
        • M. Schneider, G. Mathé, L. Schwarzenberg, P. Pouillart, R. Weiner, J. L. Amiel et al.
        Pages 42-53

    3. Specific

      1. Kinetics of Specific Cell-Mediated Immune Response in Cancer-Bearing Hosts
        • G. Barski, J. K. Youn, D. Le François
        Pages 54-57
      2. Technical and Interpretative Problems with Immunofluorescence
        • M. G. Lewis
        Pages 58-66
      3. Patterns of Cellular Immunity in Malignant Melanoma
        • D. A. Clark, L. Nathanson
        Pages 67-78
      4. Lymphocyte-Defined Histocompatibility Differences as a Model for Tumor Antigens
        • M. B. Widmer, Miriam Segall, F. H. Bach, Marilyn L. Bach
        Pages 79-83
      5. Cell-Mediated Immunity to Human Solid Tumors: <i>in vitro</i> Detection by Lymphocyte Blastogenic Responses to Cell-Associated and Solubilized Tumor Antigens
        • G. M. Mavligit, J. U. Gutterman, Ch. M. McBride, E. M. Hersh
        Pages 84-96
      6. Cell-Mediated and Humoral Immune Response to Acute Leukemia Cells and Soluble Leukemia Antigen-Relationship to Immunocompetence and Prognosis
        • J. U. Gutterman, E. M. Hersh, G. Mavligit, E. J. Freireich, R. D. Rossen, W. T. Butler et al.
        Pages 97-112
      7. Lymphocyte Cytotoxicity in Human Acute Leukemia
        • B. G. Leventhal, R. H. Halterman, E. B. Rosenberg, J. L. McCoy, R. B. Herberman
        Pages 113-117
      8. Lymphocyte-Mediated Cytotoxicity and Tumor Immunity
        • J.-C. Cerottini
        Pages 118-121
      9. Cell-Mediated Immunity in Allogeneic and Tumor-Systems: Nature of the Cells Involved in Killing Target Cells
        • J. C. Leclerc, J. P. Levy, E. Gomard, F. Plata, F. M. Kourilsky
        Pages 122-126
      10. Inhibition of Leukocyte Migration in Man
        • H. G. Remold
        Pages 127-128
      11. Effect of Autologous Serum on <i>in vitro</i> Inhibition of Leukocyte Migration by Autochthonous Tumor Extracts from Human Patients
        • F. Lacour, J. Lacour, A. Spira, S. Bayet
        Pages 129-132
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Keywords

About this book

G.MATHE Institut de Cancerologie et d'Immunogenetique (INSERM et Association Claude-Bernad), H6pital Paul-Brousse and Institute Gustave-Roussy, Villejuif 20 years ago, the main, if not only object of the cancer therapist was to effect complete surgical exeresis or radiotherapeutic destruction of a local tumor, or to obtain, by means of chemotherapy, an "apparently complete regression" of a local or disseminated neoplasia. Today it is realized that (a) at the time of the operation or radiotherapy, two patients in every three carrying an apparently localized tumor have a few cancer cells outside the area where the tumor seems localized; (b) when "apparently complete regression" or even an "apparently complete remission" is induced by chemotherapy, not all the neoplastic cells have been eradicated. In both cases an imperceptible residual neoplasm persists, the growth of which will in due course make it perceptible again, giving rise to metastasis or to a systemic or localized relapse. There is thus an urgent need for a new technique capable of killing the last cell or cells. Our experiments in mice on the effectiveness of active immunotherapy, which involves the manipulation of the immune machinery, have shown that this treatment is able to kill all the cells, down to the very last cell of a given leukemia, provided that the total number of cells does not exceed a few thousand [1, 2].

Editors and Affiliations

  • Institut de Cancérologie et d’Immunogénétique, Villejuif, France

    Georges Mathé

  • Children’s Cancer Research Foundation, Boston, USA

    Roy Weiner

Bibliographic Information

  • Book Title: Investigation and Stimulation of Immunity in Cancer Patients

  • Editors: Georges Mathé, Roy Weiner

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-49284-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1974

  • Softcover ISBN: 978-3-642-49286-0Published: 24 October 2012

  • eBook ISBN: 978-3-642-49284-6Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: IX, 504

  • Topics: Medicine/Public Health, general

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